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Anti-Dengue Virus C...
Anti-Dengue Virus Constituents from Formosan Zoanthid Palythoa mutuki
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- Lee, Jin-Ching (författare)
- Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Dept Biotechnol, Coll Life Sci, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Res Ctr Nat Prod & Drug Dev, Kaohsiung 807, Taiwan.
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- Chang, Fang-Rong (författare)
- Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan.;Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan.;Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung 807, Taiwan.
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- Chen, Shu-Rong (författare)
- Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan.
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- Wu, Yu-Hsuan (författare)
- Natl Cheng Kung Univ, Inst Basic Med Sci, Coll Med, Tainan 701, Taiwan.;Natl Cheng Kung Univ, Coll Med, Ctr Infect Dis & Signaling Res, Tainan 701, Taiwan.
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- Hu, Hao-Chun (författare)
- Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan.
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- Wu, Yang-Chang (författare)
- China Med Univ, Sch Pharm, Coll Pharm, Taichung 404, Taiwan.;China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan.;China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan.;China Med Univ, Res Ctr Chinese Herbal Med, Taichung 404, Taiwan.
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- Backlund, Anders (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Cheng, Yuan-Bin (författare)
- Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Res Ctr Nat Prod & Drug Dev, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Ctr Infect Dis & Canc Res, Kaohsiung 807, Taiwan.
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Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan;Kaohsiung Med Univ, Dept Biotechnol, Coll Life Sci, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Res Ctr Nat Prod & Drug Dev, Kaohsiung 807, Taiwan. Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807, Taiwan.;Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan.;Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung 807, Taiwan. (creator_code:org_t)
- 2016-08-09
- 2016
- Engelska.
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Ingår i: Marine Drugs. - : MDPI AG. - 1660-3397. ; 14:8
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- A new marine ecdysteroid with an alpha-hydroxy group attaching at C-4 instead of attaching at C-2 and C-3, named palythone A (1), together with eight known compounds (2-9) were obtained from the ethanolic extract of the Formosan zoanthid Palythoa mutuki. The structures of those compounds were mainly determined by NMR spectroscopic data analyses. The absolute configuration of 1 was further confirmed by comparing experimental and calculated circular dichroism (CD) spectra. Anti-dengue virus 2 activity and cytotoxicity of five isolated compounds were evaluated using virus infectious system and [3-(4,5-dimethylthiazol-2-yl)5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assays, respectively. As a result, peridinin (9) exhibited strong antiviral activity (IC50 = 4.50 +/- 0.46 mu g/mL), which is better than that of the positive control, 2'CMC. It is the first carotene-like substance possessing anti-dengue virus activity. In addition, the structural diversity and bioactivity of the isolates were compared by using a ChemGPS-NP computational analysis. The ChemGPS-NP data suggested natural products with anti-dengue virus activity locate closely in the chemical space.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- ecdysteroid
- Palythoa mutuki
- antiviral activity
- ChemGPS-NP
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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