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Differential effect...
Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels
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- Zanchi, Davide (författare)
- Univ Basel Hosp, Dept Psychiat, CH-4012 Basel, Switzerland.
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- Meyer-Gerspach, Anne Christin (författare)
- Univ Hosp, Dept Biomed, CH-4031 Basel, Switzerland.
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- Suenderhauf, Claudia (författare)
- Univ Basel Hosp, Dept Psychiat, CH-4012 Basel, Switzerland.
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- Janach, Katharina (författare)
- Univ Hosp, Dept Biomed, CH-4031 Basel, Switzerland.
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- le Roux, Carel W. (författare)
- Univ Coll Dublin, Conway Inst, Diabet Complicat Res Ctr, Dublin, Ireland.
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- Haller, Sven (författare)
- Uppsala universitet,Radiologi,Univ Geneva, Fac Med, CH-1211 Geneva 4, Switzerland.;Affidea CDRC Ctr Diagnost Radiolog Carouge, Carouge, Switzerland.;Univ Hosp Freiburg, Dept Neuroradiol, Freiburg, Germany.;Univ Geneva, Fac Med, CH-1211 Geneva 4, Switzerland.
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- Drewe, Jurgen (författare)
- St Clara Hosp, Dept Res, Basel, Switzerland.
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- Beglinger, Christoph (författare)
- St Clara Hosp, Dept Res, Basel, Switzerland.
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- Wlnerhanssen, Bettina K. (författare)
- Univ Hosp, Dept Biomed, CH-4031 Basel, Switzerland.;St Clara Hosp, Dept Res, Basel, Switzerland.
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- Borgwardt, Stefan (författare)
- Univ Basel Hosp, Dept Psychiat, CH-4012 Basel, Switzerland.
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Univ Basel Hosp, Dept Psychiat, CH-4012 Basel, Switzerland Univ Hosp, Dept Biomed, CH-4031 Basel, Switzerland. (creator_code:org_t)
- 2016-10-20
- 2016
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Depending on their protein content, single meals can rapidly influence the uptake of amino acids into the brain and thereby modify brain functions. The current study investigates the effects of two different amino acids on the human gut-brain system, using a multimodal approach, integrating physiological and neuroimaging data. In a randomized, placebo-controlled trial, L-tryptophan, L-leucine, glucose and water were administered directly into the gut of 20 healthy subjects. Functional MRI (fMRI) in a resting state paradigm (RS), combined with the assessment of insulin and glucose blood concentration, was performed before and after treatment. Independent component analysis with dual regression technique was applied to RS-fMRI data. Results were corrected for multiple comparisons. In comparison to glucose and water, L-tryptophan consistently modifies the connectivity of the cingulate cortex in the default mode network, of the insula in the saliency network and of the sensory cortex in the somatosensory network. L-leucine has lesser effects on these functional networks. L-tryptophan and L-leucine also modified plasma insulin concentration. Finally, significant correlations were found between brain modifications after L-tryptophan administration and insulin plasma levels. This study shows that acute L-tryptophan and L-leucine intake directly influence the brain networks underpinning the food-reward system and appetite regulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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Zanchi, Davide
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Meyer-Gerspach, ...
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Suenderhauf, Cla ...
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Janach, Katharin ...
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le Roux, Carel W ...
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Haller, Sven
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visa fler...
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Drewe, Jurgen
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Beglinger, Chris ...
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Wlnerhanssen, Be ...
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Borgwardt, Stefa ...
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