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Evaluating topical ...
Evaluating topical opioid gel on donor site pain : A small randomised double blind controlled trial
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- Fransén, Jian (författare)
- Uppsala universitet,Plastikkirurgi
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- Bastami, Salumeh (författare)
- Department of Medical and Health Sciences, Division of Drug Research, Linköping University, Linköping, Sweden
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- Sjöberg, Folke (författare)
- Department of Hand-, Plastic-, and Burn Surgery, University Hospital of Linköping, Linköping, Sweden
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- Uppugunduri, Srinivas (författare)
- Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
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- Huss, Fredrik, 1971- (författare)
- Uppsala universitet,Plastikkirurgi,Burn Center, Dept of Plastic- and Maxillofacial Surgery, Uppsala University hospital, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: International Journal of Surgery Open. - : Elsevier BV. - 2405-8572. ; 4, s. 5-9
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundAutologous donor skin harvested for transplantation is a common procedure in patients with burns, and patients often feel more pain at the donor site than is justified by the extent of trauma. Topical morphine gels have been thought to have an effect on peripheral opioid receptors by creating antinociceptive and anti-inflammatory effects, which could potentially reduce the systemic use of morphine-like substances and their adverse effects.MethodsWe therefore did a paired, randomised, double-blind placebo study to investigate the effect of morphine gel and placebo on dual donor sites that had been harvested in 13 patients. Pain was measured on a visual analogue scale (VAS) 15 times in a total of 5 days.ResultsThe mean (SD) VAS was 1.6 (2.3) for all sites, 1.5 (2.2) for morphine, and 2.0 (2.5) for placebo. The pain relieving effects of morphine gel were not significantly better than placebo.ConclusionThe assessment of pain at donor sites is subjective, and more systematic and objective studies are needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Morphine
- Pain
- Split thickness skin graft
- Topical application
- Donor site
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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