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Associations between a polymorphism in the hydroxysteroid (11-beta) dehydrogenase 1 gene, neuroticism and postpartum depression
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- Iliadis, Stavros I. (författare)
- Uppsala universitet,Obstetrik & gynekologi
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- Comasco, Erika (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Obstetrik & gynekologi
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- Hellgren, Charlotte (författare)
- Uppsala universitet,Obstetrik & gynekologi
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- Kollia, N. (författare)
- Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece
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- Sundström Poromaa, Inger (författare)
- Uppsala universitet,Obstetrik & gynekologi
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- Skalkidou, Alkistis (författare)
- Uppsala universitet,Obstetrik & gynekologi
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Journal of Affective Disorders. - : Elsevier BV. - 0165-0327 .- 1573-2517. ; 207, s. 141-147
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: This study examined the association between a single nucleotide polymorphism in the hydroxysteroid (11-beta) dehydrogenase 1 gene and neuroticism, as well as the possible mediatory role of neuroticism in the association between the polymorphism and postpartum depressive symptoms.METHODS: 769 women received questionnaires containing the Edinburgh Postnatal Depression Scale (EPDS) at six weeks postpartum and demographic data at pregnancy week 17 and 32 and at six weeks postpartum, as well as the Swedish universities Scales of Personality at pregnancy week 32.RESULTS: Linear regression models showed an association between the GG genotype and depressive symptoms. When neuroticism was introduced in the model, it was associated with EPDS score, whereas the association between the GG genotype and EPDS became borderline significant. A path analysis showed that neuroticism had a mediatory role in the association between the polymorphism and EPDS score.LIMITATIONS: The use of the EPDS, which is a self-reporting instrument.CONCLUSIONS: Neuroticism was associated with the polymorphism and had a mediatory role in the association between the polymorphism and postpartum depression. This finding elucidates the genetic background of neuroticism and postpartum depression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Depression
- Endophenotype
- Neuroticism
- Polymorphism
- Postpartum
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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