Sökning: onr:"swepub:oai:DiVA.org:uu-310029" >
Diphtheria toxin-me...
Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema
-
- Gardenier, Jason C. (författare)
- Mem Sloan Kettering Canc Ctr, Dept Surg, Div Plast & Reconstruct Surg, 1275 York Ave, New York, NY 10021 USA.
-
- Hespe, Geoffrey E. (författare)
- Mem Sloan Kettering Canc Ctr, Dept Surg, Div Plast & Reconstruct Surg, 1275 York Ave, New York, NY 10021 USA.
-
- Kataru, Raghu P. (författare)
- Mem Sloan Kettering Canc Ctr, Dept Surg, Div Plast & Reconstruct Surg, 1275 York Ave, New York, NY 10021 USA.
-
visa fler...
-
- Savetsky, Ira L. (författare)
- Mem Sloan Kettering Canc Ctr, Dept Surg, Div Plast & Reconstruct Surg, 1275 York Ave, New York, NY 10021 USA.
-
- Torrisi, Jeremy S. (författare)
- Mem Sloan Kettering Canc Ctr, Dept Surg, Div Plast & Reconstruct Surg, 1275 York Ave, New York, NY 10021 USA.
-
- Nores, Gabriela D. Garcia (författare)
- Mem Sloan Kettering Canc Ctr, Dept Surg, Div Plast & Reconstruct Surg, 1275 York Ave, New York, NY 10021 USA.
-
- Dayan, Joseph J. (författare)
- Mem Sloan Kettering Canc Ctr, Dept Surg, Div Plast & Reconstruct Surg, 1275 York Ave, New York, NY 10021 USA.
-
- Chang, David (författare)
- Univ Chicago Med & Biol Sci, Sect Plast & Reconstruct Surg, Chicago, IL USA.
-
- Zampell, Jamie (författare)
- Mem Sloan Kettering Canc Ctr, Dept Surg, Div Plast & Reconstruct Surg, 1275 York Ave, New York, NY 10021 USA.
-
- Martinez-Corral, Ines (författare)
- Uppsala universitet,Vaskulärbiologi
-
- Ortega, Sagrario (författare)
- Spanish Natl Canc Res Ctr CNIO, Transgen Mice Unit, Biotechnol Programme, Madrid, Spain.
-
- Mehrara, Babak J. (författare)
- Mem Sloan Kettering Canc Ctr, Dept Surg, Div Plast & Reconstruct Surg, 1275 York Ave, New York, NY 10021 USA.
-
visa färre...
-
Mem Sloan Kettering Canc Ctr, Dept Surg, Div Plast & Reconstruct Surg, 1275 York Ave, New York, NY 10021 USA Univ Chicago Med & Biol Sci, Sect Plast & Reconstruct Surg, Chicago, IL USA. (creator_code:org_t)
- American Society for Clinical Investigation, 2016
- 2016
- Engelska.
-
Ingår i: JCI INSIGHT. - : American Society for Clinical Investigation. - 2379-3708. ; 1:15
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
http://insight.jci.o...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Development of novel treatments for lymphedema has been limited by the fact that the pathophysiology of this disease is poorly understood. It remains unknown, for example, why limb swelling resulting from surgical injury resolves initially, but recurs in some cases months or years later. Finding answers for these basic questions has been hampered by the lack of adequate animal models. In the current study, we used Cre-lox mice that expressed the human diphtheria toxin receptor (DTR) driven by a lymphatic-specific promoter in order to noninvasively ablate the lymphatic system of the hind limb. Animals treated in this manner developed lymphedema that was indistinguishable from clinical lymphedema temporally, radiographically, and histologically. Using this model and clinical biopsy specimens, we show that the initial resolution of edema after injury is dependent on the formation of collateral capillary lymphatics and that this process is regulated by M2-polarized macrophages. In addition, we show that despite these initial improvements in lymphatic function, persistent accumulation of CD4(+) cells inhibits lymphangiogenesis and promotes sclerosis of collecting lymphatics, resulting in late onset of edema and fibrosis. Our findings therefore provide strong evidence that inflammatory changes after lymphatic injury play a key role in the pathophysiology of lymphedema.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Gardenier, Jason ...
-
Hespe, Geoffrey ...
-
Kataru, Raghu P.
-
Savetsky, Ira L.
-
Torrisi, Jeremy ...
-
Nores, Gabriela ...
-
visa fler...
-
Dayan, Joseph J.
-
Chang, David
-
Zampell, Jamie
-
Martinez-Corral, ...
-
Ortega, Sagrario
-
Mehrara, Babak J ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Farmakologi och ...
- Artiklar i publikationen
-
JCI INSIGHT
- Av lärosätet
-
Uppsala universitet