SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-312415"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-312415" > Post-mortem histopa...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004104naa a2200505 4500
001oai:DiVA.org:uu-312415
003SwePub
008170109s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3124152 URI
0247 a https://doi.org/10.1186/s40478-016-0399-z2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ikonomovic, Milos D4 aut
2451 0a Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection
264 c 2016-12-12
264 1b Springer Science and Business Media LLC,c 2016
338 a electronic2 rdacarrier
520 a In vivo imaging of fibrillar β-amyloid deposits may assist clinical diagnosis of Alzheimer's disease (AD), aid treatment selection for patients, assist clinical trials of therapeutic drugs through subject selection, and be used as an outcome measure. A recent phase III trial of [(18)F]flutemetamol positron emission tomography (PET) imaging in 106 end-of-life subjects demonstrated the ability to identify fibrillar β-amyloid by comparing in vivo PET to post-mortem histopathology. Post-mortem analyses demonstrated a broad and continuous spectrum of β-amyloid pathology in AD and other dementing and non-dementing disease groups. The GE067-026 trial demonstrated 91% sensitivity and 90% specificity of [(18)F]flutemetamol PET by majority read for the presence of moderate or frequent plaques. The probability of an abnormal [(18)F]flutemetamol scan increased with neocortical plaque density and AD diagnosis. All dementia cases with non-AD neurodegenerative diseases and those without histopathological features of β-amyloid deposits were [(18)F]flutemetamol negative. Majority PET assessments accurately reflected the amyloid plaque burden in 90% of cases. However, ten cases demonstrated a mismatch between PET image interpretations and post-mortem findings. Although tracer retention was best associated with amyloid in neuritic plaques, amyloid in diffuse plaques and cerebral amyloid angiopathy best explain three [(18)F]flutemetamol positive cases with mismatched (sparse) neuritic plaque burden. Advanced cortical atrophy was associated with the seven false negative [(18)F]flutemetamol images. The interpretation of images from pathologically equivocal cases was associated with low reader confidence and inter-reader agreement. Our results support that amyloid in neuritic plaque burden is the primary form of β-amyloid pathology detectable with [(18)F]flutemetamol PET imaging.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
7001 a Buckley, Chris J4 aut
7001 a Heurling, Kerstinu Uppsala universitet,Radiologi,GE Healthcare, S-75184 Uppsala, Sweden4 aut0 (Swepub:uu)kerhe556
7001 a Sherwin, Paul4 aut
7001 a Jones, Paul A4 aut
7001 a Zanette, Michelle4 aut
7001 a Mathis, Chester A4 aut
7001 a Klunk, William E4 aut
7001 a Chakrabarty, Aruna4 aut
7001 a Ironside, James4 aut
7001 a Ismail, Azzam4 aut
7001 a Smith, Colin4 aut
7001 a Thal, Dietmar R4 aut
7001 a Beach, Thomas G4 aut
7001 a Farrar, Gill4 aut
7001 a Smith, Adrian P L4 aut
7102 a Uppsala universitetb Radiologi4 org
7730 t Acta neuropathologica communicationsd : Springer Science and Business Media LLCg 4q 4x 2051-5960
8564 u https://doi.org/10.1186/s40478-016-0399-zy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1063239/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-016-0399-z
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-312415
8564 8u https://doi.org/10.1186/s40478-016-0399-z

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy