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The RhoGEF Zizimin-...
The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42
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- Sampson, Christopher J. (författare)
- Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen, Scotland.
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- Valanne, Susanna (författare)
- Univ Tampere, Inst Biomed Technol, FIN-33101 Tampere, Finland.;Univ Tampere, BioMediTech, FIN-33101 Tampere, Finland.
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- Fauvarque, Marie-Odile (författare)
- CEA, iRTSV, LBGE, F-38054 Grenoble, France.;INSERM, U1038, F-38054 Grenoble, France.;Univ Grenoble 1, F-38041 Grenoble, France.
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- Hultmark, Dan (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Ramet, Mika (författare)
- Univ Tampere, Inst Biomed Technol, FIN-33101 Tampere, Finland.;Univ Tampere, BioMediTech, FIN-33101 Tampere, Finland.;Tampere Univ Hosp, Dept Pediat, Tampere, Finland.
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- Williams, Michael J. (författare)
- Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen, Scotland.
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Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen, Scotland Univ Tampere, Inst Biomed Technol, FIN-33101 Tampere, Finland.;Univ Tampere, BioMediTech, FIN-33101 Tampere, Finland. (creator_code:org_t)
- Elsevier BV, 2012
- 2012
- Engelska.
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Ingår i: Developmental and Comparative Immunology. - : Elsevier BV. - 0145-305X .- 1879-0089. ; 38:1, s. 160-168
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Zizimin-related (Zir), a Rho guanine nucleotide exchange factor (RhoGEF) homologous to the mammalian Dock-C/Zizimin-related family, was identified in a screen to find new genes involved in the Drosophila melanogaster cellular immune response against eggs from the parasitoid wasp Leptopilina boulardi. Rho-GEFs activate Rho-family GTPases, which are known to be central regulators of cell migration, spreading and polarity. When a parasitoid wasp is recognized as foreign, multiple layers of circulating immunosurveillance cells (haemocytes) should attach to the egg. In Zir mutants this process is disrupted and lamellocytes, a haemocyte subtype, fail to properly encapsulate the wasp egg. Furthermore, macrophage-like plasmatocytes exhibit a strong reduction in their ability to phagocytise Escherichia coli and Staphylococcus aureus bacteria. During encapsulation and phagocytosis Zir genetically interacts with two Rho-family GTPases, Rac2 and Cdc42. Finally, Zir is dispensable for the humoral immune response against bacteria. We propose that Zir is necessary to activate the Rho-family GTPases Rac2 and Cdc42 during the Drosophila cellular immune response.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Haemocyte
- Small GTPase
- Innate immunity
- Cellular immunity
- Rho GTPase
- Parasitization
- Phagocytosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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