onr:"swepub:oai:DiVA.org:uu-317994"
Sökning: onr:"swepub:oai:DiVA.org:uu-317994" > Genome-wide associa...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06434naa a2201537 4500 | |
| 001 | oai:DiVA.org:uu-317994 | |
| 003 | SwePub | |
| 008 | 170323s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3179942 URI |
| 024 | 7 | a https://doi.org/10.1038/ng.37872 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wain, Louise V4 aut |
| 245 | 1 0 | a Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. |
| 264 | c 2017-02-06 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2017 |
| 338 | a print2 rdacarrier | |
| 520 | a Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (∼6 alleles) (95% confidence interval) = 1.24 (1.20-1.27), P = 5.05 × 10(-49)), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications. | |
| 700 | 1 | a Shrine, Nick4 aut |
| 700 | 1 | a Artigas, María Soler4 aut |
| 700 | 1 | a Erzurumluoglu, A Mesut4 aut |
| 700 | 1 | a Noyvert, Boris4 aut |
| 700 | 1 | a Bossini-Castillo, Lara4 aut |
| 700 | 1 | a Obeidat, Ma'en4 aut |
| 700 | 1 | a Henry, Amanda P4 aut |
| 700 | 1 | a Portelli, Michael A4 aut |
| 700 | 1 | a Hall, Robert J4 aut |
| 700 | 1 | a Billington, Charlotte K4 aut |
| 700 | 1 | a Rimington, Tracy L4 aut |
| 700 | 1 | a Fenech, Anthony G4 aut |
| 700 | 1 | a John, Catherine4 aut |
| 700 | 1 | a Blake, Tineka4 aut |
| 700 | 1 | a Jackson, Victoria E4 aut |
| 700 | 1 | a Allen, Richard J4 aut |
| 700 | 1 | a Prins, Bram P4 aut |
| 700 | 1 | a Campbell, Archie4 aut |
| 700 | 1 | a Porteous, David J4 aut |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Wielscher, Matthias4 aut |
| 700 | 1 | a James, Alan L4 aut |
| 700 | 1 | a Hui, Jennie4 aut |
| 700 | 1 | a Wareham, Nicholas J4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Wilson, James F4 aut |
| 700 | 1 | a Joshi, Peter K4 aut |
| 700 | 1 | a Stubbe, Beate4 aut |
| 700 | 1 | a Rawal, Rajesh4 aut |
| 700 | 1 | a Schulz, Holger4 aut |
| 700 | 1 | a Imboden, Medea4 aut |
| 700 | 1 | a Probst-Hensch, Nicole M4 aut |
| 700 | 1 | a Karrasch, Stefan4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Deary, Ian J4 aut |
| 700 | 1 | a Harris, Sarah E4 aut |
| 700 | 1 | a Marten, Jonathan4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Enroth, Stefanu Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)stenr451 |
| 700 | 1 | a Gyllensten, Ulf B.u Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ulfgyll |
| 700 | 1 | a Kerr, Shona M4 aut |
| 700 | 1 | a Polasek, Ozren4 aut |
| 700 | 1 | a Kähönen, Mika4 aut |
| 700 | 1 | a Surakka, Ida4 aut |
| 700 | 1 | a Vitart, Veronique4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Lehtimäki, Terho4 aut |
| 700 | 1 | a Raitakari, Olli T4 aut |
| 700 | 1 | a Evans, David M4 aut |
| 700 | 1 | a Henderson, A John4 aut |
| 700 | 1 | a Pennell, Craig E4 aut |
| 700 | 1 | a Wang, Carol A4 aut |
| 700 | 1 | a Sly, Peter D4 aut |
| 700 | 1 | a Wan, Emily S4 aut |
| 700 | 1 | a Busch, Robert4 aut |
| 700 | 1 | a Hobbs, Brian D4 aut |
| 700 | 1 | a Litonjua, Augusto A4 aut |
| 700 | 1 | a Sparrow, David W4 aut |
| 700 | 1 | a Gulsvik, Amund4 aut |
| 700 | 1 | a Bakke, Per S4 aut |
| 700 | 1 | a Crapo, James D4 aut |
| 700 | 1 | a Beaty, Terri H4 aut |
| 700 | 1 | a Hansel, Nadia N4 aut |
| 700 | 1 | a Mathias, Rasika A4 aut |
| 700 | 1 | a Ruczinski, Ingo4 aut |
| 700 | 1 | a Barnes, Kathleen C4 aut |
| 700 | 1 | a Bossé, Yohan4 aut |
| 700 | 1 | a Joubert, Philippe4 aut |
| 700 | 1 | a van den Berge, Maarten4 aut |
| 700 | 1 | a Brandsma, Corry-Anke4 aut |
| 700 | 1 | a Paré, Peter D4 aut |
| 700 | 1 | a Sin, Don D4 aut |
| 700 | 1 | a Nickle, David C4 aut |
| 700 | 1 | a Hao, Ke4 aut |
| 700 | 1 | a Gottesman, Omri4 aut |
| 700 | 1 | a Dewey, Frederick E4 aut |
| 700 | 1 | a Bruse, Shannon E4 aut |
| 700 | 1 | a Carey, David J4 aut |
| 700 | 1 | a Kirchner, H Lester4 aut |
| 700 | 1 | a Jonsson, Stefan4 aut |
| 700 | 1 | a Thorleifsson, Gudmar4 aut |
| 700 | 1 | a Jonsdottir, Ingileif4 aut |
| 700 | 1 | a Gislason, Thorarinn4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a Schurmann, Claudia4 aut |
| 700 | 1 | a Nadkarni, Girish4 aut |
| 700 | 1 | a Bottinger, Erwin P4 aut |
| 700 | 1 | a Loos, Ruth J F4 aut |
| 700 | 1 | a Walters, Robin G4 aut |
| 700 | 1 | a Chen, Zhengming4 aut |
| 700 | 1 | a Millwood, Iona Y4 aut |
| 700 | 1 | a Vaucher, Julien4 aut |
| 700 | 1 | a Kurmi, Om P4 aut |
| 700 | 1 | a Li, Liming4 aut |
| 700 | 1 | a Hansell, Anna L4 aut |
| 700 | 1 | a Brightling, Chris4 aut |
| 700 | 1 | a Zeggini, Eleftheria4 aut |
| 700 | 1 | a Cho, Michael H4 aut |
| 700 | 1 | a Silverman, Edwin K4 aut |
| 700 | 1 | a Sayers, Ian4 aut |
| 700 | 1 | a Trynka, Gosia4 aut |
| 700 | 1 | a Morris, Andrew P4 aut |
| 700 | 1 | a Strachan, David P4 aut |
| 700 | 1 | a Hall, Ian P4 aut |
| 700 | 1 | a Tobin, Martin D4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org |
| 773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 49:3, s. 416-425q 49:3<416-425x 1061-4036x 1546-1718 |
| 856 | 4 | u https://europepmc.org/articles/pmc5326681?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317994 |
| 856 | 4 8 | u https://doi.org/10.1038/ng.3787 |
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Wain, Louise V
- Shrine, Nick
- Artigas, María S ...
- Erzurumluoglu, A ...
- Noyvert, Boris
- Bossini-Castillo ...
- visa fler...
- Obeidat, Ma'en
- Henry, Amanda P
- Portelli, Michae ...
- Hall, Robert J
- Billington, Char ...
- Rimington, Tracy ...
- Fenech, Anthony ...
- John, Catherine
- Blake, Tineka
- Jackson, Victori ...
- Allen, Richard J
- Prins, Bram P
- Campbell, Archie
- Porteous, David ...
- Jarvelin, Marjo- ...
- Wielscher, Matth ...
- James, Alan L
- Hui, Jennie
- Wareham, Nichola ...
- Zhao, Jing Hua
- Wilson, James F
- Joshi, Peter K
- Stubbe, Beate
- Rawal, Rajesh
- Schulz, Holger
- Imboden, Medea
- Probst-Hensch, N ...
- Karrasch, Stefan
- Gieger, Christia ...
- Deary, Ian J
- Harris, Sarah E
- Marten, Jonathan
- Rudan, Igor
- Enroth, Stefan
- Gyllensten, Ulf ...
- Kerr, Shona M
- Polasek, Ozren
- Kähönen, Mika
- Surakka, Ida
- Vitart, Veroniqu ...
- Hayward, Carolin ...
- Lehtimäki, Terho
- Raitakari, Olli ...
- Evans, David M
- Henderson, A Joh ...
- Pennell, Craig E
- Wang, Carol A
- Sly, Peter D
- Wan, Emily S
- Busch, Robert
- Hobbs, Brian D
- Litonjua, August ...
- Sparrow, David W
- Gulsvik, Amund
- Bakke, Per S
- Crapo, James D
- Beaty, Terri H
- Hansel, Nadia N
- Mathias, Rasika ...
- Ruczinski, Ingo
- Barnes, Kathleen ...
- Bossé, Yohan
- Joubert, Philipp ...
- van den Berge, M ...
- Brandsma, Corry- ...
- Paré, Peter D
- Sin, Don D
- Nickle, David C
- Hao, Ke
- Gottesman, Omri
- Dewey, Frederick ...
- Bruse, Shannon E
- Carey, David J
- Kirchner, H Lest ...
- Jonsson, Stefan
- Thorleifsson, Gu ...
- Jonsdottir, Ingi ...
- Gislason, Thorar ...
- Stefansson, Kari
- Schurmann, Claud ...
- Nadkarni, Girish
- Bottinger, Erwin ...
- Loos, Ruth J F
- Walters, Robin G
- Chen, Zhengming
- Millwood, Iona Y
- Vaucher, Julien
- Kurmi, Om P
- Li, Liming
- Hansell, Anna L
- Brightling, Chri ...
- Zeggini, Elefthe ...
- Cho, Michael H
- Silverman, Edwin ...
- Sayers, Ian
- Trynka, Gosia
- Morris, Andrew P
- Strachan, David ...
- Hall, Ian P
- Tobin, Martin D
- visa färre...
- Artiklar i publikationen
- Nature Genetics
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
