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The risk of renal d...
The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
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- Kozlowski, Piotr, 1969- (författare)
- Region Örebro län,Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Montgomery, Scott, 1961- (författare)
- Karolinska Institutet,Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, UK,Clinical Epidemiology and Biostatistics
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- Befekadu, Rahel, 1968- (författare)
- Univ Orebro, Sch Med Sci, Dept Transfus Med, Orebro, Sweden.,Örebro universitet, Institutionen för medicinska vetenskaper,Department of Transfusion Medicine, Faculty of Medical Sciences, Örebro University, Örebro, Sweden,Clinical Epidemiology and Biostatistics
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- Hahn-Strömberg, Victoria (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- DOVE MEDICAL PRESS LTD, 2017
- 2017
- Engelska.
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Ingår i: Journal of Blood Medicine. - : DOVE MEDICAL PRESS LTD. - 1179-2736. ; 8, s. 29-34
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.2...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Light chain amyloidosis (AL) is a rare deposition disease and is present in 10-15% of patients with myeloma (MM). In contrast to symptomatic AL in MM, presence of bone marrow (BM) amyloid deposits (AD) in MM is not connected to kidney damage. Renal AD but not BM-AD occur mostly in MM with lambda paraprotein (lambda MM). Methods: We investigated amyloid presence in BM clots taken at diagnosis in 84 patients with symptomatic MM and compared disease characteristics in MM with kappa paraprotein (kappa MM)/lambda MM with and without BM-AD. Results: Lambda MM with BM-AD was compared with kappa MM without BM-AD, kappa MM with BM-AD, and lambda MM without BM-AD: lambda MM with BM-AD patients had a significantly higher mean creatinine level (4.23 mg/dL vs 1.69, 1.14, and 1.28 mg/dL, respectively) and a higher proportion presented with severe kidney failure (6/11 [55%] vs 6/32 [19%], 1/22 [5%], and 3/19 [16%], respectively). Proteinuria was more common in lambda MM with BM-AD patients compared with kappa MM without BM-AD patients (8/11 [73%] vs 5/32 [16%], respectively). Conclusion: Kidney damage was more common in lambda MM with BM-AD indicating presence of renal AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- plasma cells
- neoplasms
- amyloidosis
- renal insufficiency
- proteinuria
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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