Sökning: onr:"swepub:oai:DiVA.org:uu-319488" >
Evaluation of ECG-g...
Evaluation of ECG-gated [(11)C]acetate PET for measuring left ventricular volumes, mass, and myocardial external efficiency
-
Hansson, Nils Henrik (författare)
-
Tolbod, Lars (författare)
-
Harms, Johannes (författare)
-
visa fler...
-
Wiggers, Henrik (författare)
-
Kim, Won Yong (författare)
-
Hansen, Esben (författare)
-
Zaremba, Tomas (författare)
-
Frøkiær, Jørgen (författare)
-
Jakobsen, Steen (författare)
-
- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi
-
visa färre...
-
(creator_code:org_t)
- 2016-04-19
- 2016
- Engelska.
-
Ingår i: Journal of Nuclear Cardiology. - : Springer Science and Business Media LLC. - 1071-3581 .- 1532-6551. ; 23:4, s. 670-9
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Noninvasive estimation of myocardial external efficiency (MEE) requires measurements of left ventricular (LV) oxygen consumption with [(11)C]acetate PET in addition to LV stroke volume and mass with cardiovascular magnetic resonance (CMR). Measuring LV geometry directly from ECG-gated [(11)C]acetate PET might enable MEE evaluation from a single PET scan. Therefore, we sought to establish the accuracy of measuring LV volumes, mass, and MEE directly from ECG-gated [(11)C]acetate PET.METHODS: Thirty-five subjects with aortic valve stenosis underwent ECG-gated [(11)C]acetate PET and CMR. List mode PET data were rebinned into 16-bin ECG-gated uptake images before measuring LV volumes and mass using commercial software and compared to CMR. Dynamic datasets were used for calculation of mean LV oxygen consumption and MEE.RESULTS: LV mass, volumes, and ejection fraction measured by CMR and PET correlated strongly (r = 0.86-0.92, P < .001 for all), but were underestimated by PET (P < .001 for all except ESV P = .79). PET-based MEE, corrected for bias, correlated fairly with PET/CMR-based MEE (r = 0.60, P < .001, bias -3 ± 21%, P = .56). PET-based MEE bias was strongly associated with LV wall thickness.CONCLUSIONS: Although analysis-related improvements in accuracy are recommended, LV geometry estimated from ECG-gated [(11)C]acetate PET correlate excellently with CMR and can indeed be used to evaluate MEE.
Nyckelord
- Myocardial external efficiency
- PET imaging
- magnetic resonance imaging
- metabolism: PET
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hansson, Nils He ...
-
Tolbod, Lars
-
Harms, Johannes
-
Wiggers, Henrik
-
Kim, Won Yong
-
Hansen, Esben
-
visa fler...
-
Zaremba, Tomas
-
Frøkiær, Jørgen
-
Jakobsen, Steen
-
Sörensen, Jens
-
visa färre...
- Artiklar i publikationen
-
Journal of Nucle ...
- Av lärosätet
-
Uppsala universitet