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Neutron Reflectomet...
Neutron Reflectometry reveals the interaction between functionalized SPIONs and the surface of lipid bilayers
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- Luchini, Alessandra (författare)
- Univ Napoli Federico 11, Dipartimento Sci Chim, Complesso Univ Monte S Angelo,Via Cintia, I-80126 Naples, Italy.;CSGI Consorzio Interuniv Sviluppo Sistemi Grande, Sesto Fiorentino, Italy.;Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France.,University of Naples Federico II,Institut Laue Langevin
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- Gerelli, Yuri (författare)
- Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin
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- Fragneto, Giovanna (författare)
- Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin
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- Nylander, Tommy (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Pálsson, Gunnar K. (författare)
- Uppsala University,Uppsala universitet,Materialfysik,Inst Laue Langevin, 71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin
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- Appavou, Marie-Sousai (författare)
- Garching Forschungszentrum, Julich Ctr Neutron Sci, Lichtenbergstr 1, D-85747 Garching, Germany.,Jülich Research Centre
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- Paduano, Luigi (författare)
- Univ Napoli Federico 11, Dipartimento Sci Chim, Complesso Univ Monte S Angelo,Via Cintia, I-80126 Naples, Italy.;CSGI Consorzio Interuniv Sviluppo Sistemi Grande, Sesto Fiorentino, Italy.,University of Naples Federico II
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Univ Napoli Federico 11, Dipartimento Sci Chim, Complesso Univ Monte S Angelo,Via Cintia, I-80126 Naples, Italy;CSGI Consorzio Interuniv Sviluppo Sistemi Grande, Sesto Fiorentino, Italy.;Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France. University of Naples Federico II (creator_code:org_t)
- ELSEVIER SCIENCE BV, 2017
- 2017
- Engelska.
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Ingår i: Colloids and Surfaces B. - : ELSEVIER SCIENCE BV. - 0927-7765 .- 1873-4367. ; 151, s. 76-87
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- The safe application of nanotechnology devices in biomedicine requires fundamental understanding on how they interact with and affect the different components of biological systems. In this respect, the cellular membrane, the cell envelope, certainly represents an important target or barrier for nanosystems. Here we report on the interaction between functionalized SuperParamagnetic Iron Oxide Nanoparticles (SPIONs), promising contrast agents for Magnetic Resonance Imaging (MRI), and lipid bilayers that mimic the plasma membrane. Neutron Reflectometry, supported by Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) experiments, was used to characterize this interaction by varying both SPION coating and lipid bilayer composition. In particular, the interaction of two different SPIONs, functionalized with a cationic surfactant and a zwitterionic phospholipid, and lipid bilayers, containing different amount of cholesterol, were compared. The obtained results were further validated by Dynamic Light Scattering (DLS) measurements and Cryogenic Transmission Electron Microscopy (Cryo-TEM) images. None of the investigated functionalized SPIONs were found to disrupt the lipid membrane. However, in all case we observed the attachment of the functionalized SPIONs onto the surface of the bilayers, which was affected by the bilayer rigidity, i.e. the cholesterol concentration.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- SuperParamagnetic Iron Oxide
- Nanoparticles (SPIONs)
- Lysophosphatidylcholine
- Supported lipid bilayers
- Cholesterol
- Neutron reflectometry
- Cholesterol
- Lysophosphatidylcholine
- Neutron reflectometry
- SuperParamagnetic Iron Oxide Nanoparticles (SPIONs)
- Supported lipid bilayers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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