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Dose painting by nu...
Dose painting by numbers based on retrospectively determined recurrence probabilities
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- Grönlund, Eric (författare)
- Uppsala universitet,Medicinsk strålningsvetenskap
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- Johansson, Silvia (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Montelius, Anders (författare)
- Uppsala universitet,Medicinsk strålningsvetenskap
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- Ahnesjö, Anders, 1953- (författare)
- Uppsala universitet,Medicinsk strålningsvetenskap
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(creator_code:org_t)
- ELSEVIER IRELAND LTD, 2017
- 2017
- Engelska.
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Ingår i: Radiotherapy and Oncology. - : ELSEVIER IRELAND LTD. - 0167-8140 .- 1879-0887. ; 122:2, s. 236-241
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://uu.diva-port...
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http://www.thegreenj...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and purpose: The aim of this study is to derive "dose painting by numbers" prescriptions from retrospectively observed recurrence volumes in a patient group treated with conventional radiotherapy for head and neck squamous cell carcinoma. Materials and methods: The spatial relation between retrospectively observed recurrence volumes and pre-treatment standardized uptake values (SUV) from fluorodeoxyglucose positron emission tomography (FDG-PET) imaging was determined. Based on this information we derived SUV driven dose-response functions and used these to optimize ideal dose redistributions under the constraint of equal average dose to the tumor volumes as for a conventional treatment. The response functions were also implemented into a treatment planning system for realistic dose optimization. Results: The calculated tumor control probabilities (TCP) increased between 0.1-14.6% by the ideal dose redistributions for all included patients, where patients with larger and more heterogeneous tumors got greater increases than smaller and more homogeneous tumors. Conclusions: Dose painting prescriptions can be derived from retrospectively observed recurrence volumes spatial relation to pre-treatment FDG-PET image data. The ideal dose redistributions could significantly increase the TCP for patients with large tumor volumes and large spread in SUV from FDG-PET. The results yield a basis for prospective studies to determine the clinical value for dose painting of head and neck squamous cell carcinomas.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Dose painting
- Dose painting by numbers
- Dose painting optimization
- Head and neck cancer
- FDG-PET/CT
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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