Sökning: onr:"swepub:oai:DiVA.org:uu-320855" >
Predicting the Indi...
Predicting the Individual Risk of Acute Severe Colitis at Diagnosis
-
- Cesarini, Monica (författare)
- Oxford Univ Hosp, Translat Gastroenterol Unit, Oxford, England.;Sapienza Univ Rome, Dipartimento Med Interna & Specialita Med, Rome, Italy.
-
- Collins, Gary S. (författare)
- Univ Oxford, Ctr Stat Med, Oxford, England.
-
- Rönnblom, Anders (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
-
visa fler...
-
- Santos, Antonieta (författare)
- Cambridge Univ Hosp, Gastroenterol Unit, Cambridge, England.;Hosp Amato Lusitano, Gastroenterol Unit, Castelo Branco, Portugal.
-
- Wang, Lai Mun (författare)
- Oxford Univ Hosp, Dept Cellular Pathol, Oxford, England.
-
- Sjöberg, Daniel, 1974- (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
-
- Parkes, Miles (författare)
- Oxford Univ Hosp, Translat Gastroenterol Unit, Oxford, England.
-
- Keshav, Satish (författare)
- Oxford Univ Hosp, Translat Gastroenterol Unit, Oxford, England.
-
- Travis, Simon P. L. (författare)
- Oxford Univ Hosp, Translat Gastroenterol Unit, Oxford, England.
-
visa färre...
-
Oxford Univ Hosp, Translat Gastroenterol Unit, Oxford, England;Sapienza Univ Rome, Dipartimento Med Interna & Specialita Med, Rome, Italy. Univ Oxford, Ctr Stat Med, Oxford, England. (creator_code:org_t)
- 2016-09-19
- 2017
- Engelska.
-
Ingår i: Journal of Crohn's & Colitis. - : OXFORD UNIV PRESS. - 1873-9946 .- 1876-4479. ; 11:3, s. 335-341
- Relaterad länk:
-
https://academic.oup...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background and Aims: Acute severe colitis [ASC] is associated with major morbidity. We aimed to develop and externally validate an index that predicted ASC within 3 years of diagnosis. Methods: The development cohort included patients aged 16-89 years, diagnosed with ulcerative colitis [UC] in Oxford and followed for 3 years. Primary outcome was hospitalization for ASC, excluding patients admitted within 1 month of diagnosis. Multivariable logistic regression examined the adjusted association of seven risk factors with ASC. Backwards elimination produced a parsimonious model that was simplified to create an easy-to-use index. External validation occurred in separate cohorts from Cambridge, UK, and Uppsala, Sweden. Results: The development cohort [Oxford] included 34/111 patients who developed ASC within a median 14 months [range 1-29]. The final model applied the sum of 1 point each for extensive disease, C-reactive protein [CRP] >10 mg/l, or haemoglobin < 12 g/dl F or < 14 g/dl M at diagnosis, to give a score from 0/3 to 3/3. This predicted a 70% risk of developing ASC within 3 years [score 3/3]. Validation cohorts included different proportions with ASC [Cambridge = 25/96; Uppsala = 18/298]. Of those scoring 3/3 at diagnosis, 18/18 [Cambridge] and 12/13 [Uppsala] subsequently developed ASC. Discriminant ability [c-index, where 1.0 = perfect discrimination] was 0.81 [Oxford], 0.95 [Cambridge], 0.97 [Uppsala]. Internal validation using bootstrapping showed good calibration, with similar predicted risk across all cohorts. A nomogram predicted individual risk. Conclusions: An index applied at diagnosis reliably predicts the risk of ASC within 3 years in different populations. Patients with a score 3/3 at diagnosis may merit early immunomodulator therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Biomarkers
- clinical trials
- acute severe colitis
- prediction
- ulcerative colitis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Cesarini, Monica
-
Collins, Gary S.
-
Rönnblom, Anders
-
Santos, Antoniet ...
-
Wang, Lai Mun
-
Sjöberg, Daniel, ...
-
visa fler...
-
Parkes, Miles
-
Keshav, Satish
-
Travis, Simon P. ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Gastroenterologi
- Artiklar i publikationen
-
Journal of Crohn ...
- Av lärosätet
-
Uppsala universitet