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Adaptation to infec...
Adaptation to infectious disease exposure in indigenous Southern African populations
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- Owers, Katharine A. (författare)
- Uppsala universitet,Evolutionsbiologi,Yale Univ, Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT USA.
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- Sjödin, Per (författare)
- Uppsala universitet,Evolutionsbiologi
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- Schlebusch, Carina M., 1977- (författare)
- Uppsala universitet,Evolutionsbiologi
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- Skoglund, Pontus (författare)
- Uppsala universitet,Evolutionsbiologi
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- Soodyall, Himla (författare)
- Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Div Human Genet, Johannesburg, South Africa.;Natl Hlth Lab Serv, Johannesburg, South Africa.
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- Jakobsson, Mattias (författare)
- Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2017-04-05
- 2017
- Engelska.
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Ingår i: Proceedings of the Royal Society of London. Biological Sciences. - : ROYAL SOC. - 0962-8452 .- 1471-2954. ; 284:1852
- Relaterad länk:
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https://royalsociety...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Genetic analyses can provide information about human evolutionary history that cannot always be gleaned from other sources. We evaluated evidence of selective pressure due to introduced infectious diseases in the genomes of two indigenous southern African San groups-the double dagger Khomani who had abundant contact with other people migrating into the region and the more isolated Ju vertical bar'hoansi. We used a dual approach to test for increased selection on immune genes compared with the rest of the genome in these groups. First, we calculated summary values of statistics that measure genomic signatures of adaptation to contrast selection signatures in immune genes and all genes. Second, we located regions of the genome with extreme values of three selection statistics and examined these regions for enrichment of immune genes. We found stronger and more abundant signals of selection in immune genes in the double dagger Khomani than in the Ju vertical bar'hoansi. We confirm this finding within each population to avoid effects of different demographic histories of the two populations. We identified eight immune genes that have potentially been targets of strong selection in the double dagger Khomani, whereas in the Juj'hoansi, no immune genes were found in the genomic regions with the strongest signals of selection. We suggest that the more abundant signatures of selection at immune genes in the double dagger Khomani could be explained by their more frequent contact with immigrant groups, which likely led to increased exposure and adaptation to introduced infectious diseases.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Nyckelord
- population genetics
- human migrations
- introduced diseases
- immune genes
- adaptation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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