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Removal of 30 activ...
Removal of 30 active pharmaceutical ingredients in surface water under long-term artificial UV irradiation
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- Blum, Kristin M. (författare)
- Umeå universitet,Kemiska institutionen,Umea Univ, Dept Chem, S-90187 Umea, Sweden.,Department of Chemistry, Umeå University
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- Norström, Sara H. (författare)
- Umeå universitet,Kemiska institutionen,Umea Univ, Dept Chem, S-90187 Umea, Sweden.,Department of Chemistry, Umeå University,Analytisk kemi - skog och miljö
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- Golovko, Oksana (författare)
- Univ South Bohemia Ceske Budejovice, Fac Fisheries & Protect Waters, South Bohemian Res Ctr Aquaculture & Biodivers Hy, Zatisi 728-2, Vodnany 38925, Czech Republic.,South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodnany, Czech Republic
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- Grabic, Roman (författare)
- Univ South Bohemia Ceske Budejovice, Fac Fisheries & Protect Waters, South Bohemian Res Ctr Aquaculture & Biodivers Hy, Zatisi 728-2, Vodnany 38925, Czech Republic.,South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodnany, Czech Republic
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- Järhult, Josef D., 1975- (författare)
- Uppsala universitet,Infektionssjukdomar,Institutionen för medicinsk biokemi och mikrobiologi,Department of Medical Sciences, Uppsala University; Department of Medical Biochemistry and Microbiology, Uppsala University
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- Koba, Olga (författare)
- Univ South Bohemia Ceske Budejovice, Fac Fisheries & Protect Waters, South Bohemian Res Ctr Aquaculture & Biodivers Hy, Zatisi 728-2, Vodnany 38925, Czech Republic.,South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Vodnany, Czech Republic
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- Söderström Lindström, Hanna (författare)
- Umeå universitet,Kemiska institutionen,Yrkes- och miljömedicin,Umea Univ, Dept Chem, S-90187 Umea, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, Occupat & Environm Med, S-90187 Umea, Sweden.,Department of Chemistry, Umeå University; Occupational and Environmental Medicine, Umeå University
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Chemosphere. - : Elsevier BV. - 0045-6535 .- 1879-1298. ; 176, s. 175-182
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- This study investigated the i) kinetics, and ii) proportion of photolysis of 30 relatively stable active pharmaceutical ingredients (APIs) during artificial UV irradiation for 28 d in ammonium acetate buffer, filtered and unfiltered river water. Buffer was included to control removal kinetics under stable pH conditions and without particulate matter. Dark controls were used to determine removal due to other processes than photolysis and calculate the proportion of photolysis of the total removal. The removal of each API in each matrix was determined using online solid phase extraction/liquid chromatography tandem mass spectrometry (online SPE/LC-MS/MS). Most APIs transformed during the 28 d of UV irradiation and the dark controls showed that photolysis was the major removal process for the majority of the APIs studied. The half-lives ranged from 6 h (amitriptyline) in unfiltered river water to 884 h (37 d, carbamazepine) in buffer. In unfiltered river water, the proportion of APIs with short half-lives (<48 h) was much higher (29%) than in the other matrices (4%), probably due to additional organic carbon, which could have promoted indirect photolysis. Furthermore, two APIs, memantine and fluconazole, were stable in all three matrices, while alprazolam was stable in buffer and unfiltered river water and four additional APIs were stable in buffer. Considering the relatively long-term UV-exposure, this study enabled the investigation of environmentally relevant half-lives in natural waters. Many APIs showed high persistence, which is environmentally concerning and emphasizes the importance of further studies on their environmental fate and effects.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Samhällsbyggnadsteknik -- Vattenteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Civil Engineering -- Water Engineering (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Geokemi (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Geochemistry (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- Active pharmaceutical ingredients
- Oseltamivir
- Photostability
- Photolysis
- Half-lives
- Aquatic environments
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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