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Diffusion kurtosis ...
Diffusion kurtosis imaging of gliomas grades II and III : a study of perilesional tumor infiltration, tumor grades and subtypes at clinical presentation
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- Falk Delgado, Anna (författare)
- Karolinska Institutet,Uppsala University,Karolinska Institute,Uppsala universitet,Radiologi,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
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- Fahlström, Markus (författare)
- Uppsala University,Uppsala universitet,Radiologi
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- Nilsson, Markus (författare)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Faculty of Medicine,Lund University Research Groups,Lund Univ, Bioimaging Ctr, Lund, Sweden.
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- Berntsson, Shala G., 1964- (författare)
- Uppsala University,Uppsala universitet,Neurologi
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- Zetterling, Maria (författare)
- Uppsala University,Uppsala universitet,Neurokirurgi
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- Libard, Sylwia (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Irina Alfuzoff,Uppsala University Hospital
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- Alafuzoff, Irina (författare)
- Uppsala universitet,Klinisk och experimentell patologi,Irina Alufuzoff,Uppsala University Hospital
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- Van Westen, Danielle (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Lund Univ, Clin Sci Lund, Diagnost Radiol, Lund, Sweden.
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- Lätt, Jimmy (författare)
- Skane Univ Healthcare, Dept Imaging & Funct, Lund, Sweden.,Skåne University Hospital
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- Smits, Anja (författare)
- Uppsala University,Uppsala universitet,Neurologi
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- Larsson, Elna-Marie (författare)
- Uppsala University,Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2017-02-15
- 2017
- Engelska.
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Ingår i: Radiology and Oncology. - : Walter de Gruyter GmbH. - 1318-2099 .- 1581-3207. ; 51:2, s. 121-129
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://content.scie...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background. Diffusion kurtosis imaging (DKI) allows for assessment of diffusion influenced by microcellular structures. We analyzed DKI in suspected low-grade gliomas prior to histopathological diagnosis. The aim was to investigate if diffusion parameters in the perilesional normal-appearing white matter (NAWM) differed from contralesional white matter, and to investigate differences between glioma malignancy grades II and III and glioma subtypes (astrocytomas and oligodendrogliomas).Patients and methods. Forty-eight patients with suspected low-grade glioma were prospectively recruited to this institutional review board-approved study and investigated with preoperative DKI at 3T after written informed consent. Patients with histologically proven glioma grades II or III were further analyzed (n=35). Regions of interest (ROIs) were delineated on T2FLAIR images and co-registered to diffusion MRI parameter maps. Mean DKI data were compared between perilesional and contralesional NAWM (student's t-test for dependent samples, Wilcoxon matched pairs test). Histogram DKI data were compared between glioma types and glioma grades (multiple comparisons of mean ranks for all groups). The discriminating potential for DKI in assessing glioma type and grade was assessed with receiver operating characteristics (ROC) curves.Results. There were significant differences in all mean DKI variables between perilesional and contralesional NAWM (p=< 0.000), except for axial kurtosis (p=0.099). Forty-four histogram variables differed significantly between glioma grades II (n=23) and III (n=12) (p=0.003-0.048) and 10 variables differed significantly between ACs (n=18) and ODs (n=17) (p=0.011-0.050). ROC curves of the best discriminating variables had an area under the curve (AUC) of 0.657-0.815.Conclusions. Mean DKI variables in perilesional NAWM differ significantly from contralesional NAWM, suggesting altered microstructure by tumor infiltration not depicted on morphological MRI. Histogram analysis of DKI data identifies differences between glioma grades and subtypes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- diffusion kurtosis imaging (DKI)
- glioma
- perilesional
- tumor infiltration
- grade
- subtype
- Patologi
- Pathology
- diffusion kurtosis imaging (DKI)
- glioma
- grade
- perilesional
- subtype
- tumor infiltration
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Falk Delgado, An ...
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Fahlström, Marku ...
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Nilsson, Markus
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Berntsson, Shala ...
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Zetterling, Mari ...
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Libard, Sylwia
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visa fler...
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Alafuzoff, Irina
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Van Westen, Dani ...
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Lätt, Jimmy
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Smits, Anja
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Larsson, Elna-Ma ...
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Radiology and On ...
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet