The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation.

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Fältnamn	Indikatorer	Metadata
000		06923naa a2201213 4500
001		oai:DiVA.org:uu-325672
003		SwePub
008		170627s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:136090653
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3256722 URI
024	7	a https://doi.org/10.1186/s13229-017-0145-92 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1360906532 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Charman, Tony4 aut
245	1 0	a The EU-AIMS Longitudinal European Autism Project (LEAP) :b clinical characterisation.
264		c 2017-06-23
264	1	b Springer Science and Business Media LLC,c 2017
338		a electronic2 rdacarrier
520		a BACKGROUND: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers.METHODS: From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms.RESULTS: The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females.CONCLUSIONS: The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort. Variation both in core ASD symptom severity and in commonly co-occurring psychiatric symptoms were systematically associated with sex, age and IQ. The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653		a Age
653		a Autism
653		a Autism spectrum disorder
653		a Behaviours
653		a Heterogeneity
653		a IQ
653		a Phenotype
653		a Sex
700	1	a Loth, Eva4 aut
700	1	a Tillmann, Julian4 aut
700	1	a Crawley, Daisy4 aut
700	1	a Wooldridge, Caroline4 aut
700	1	a Goyard, David4 aut
700	1	a Ahmad, Jumana4 aut
700	1	a Auyeung, Bonnie4 aut
700	1	a Ambrosino, Sara4 aut
700	1	a Banaschewski, Tobias4 aut
700	1	a Baron-Cohen, Simon4 aut
700	1	a Baumeister, Sarah4 aut
700	1	a Beckmann, Christian4 aut
700	1	a Bölte, Svenu Karolinska Institutet4 aut
700	1	a Bourgeron, Thomas4 aut
700	1	a Bours, Carsten4 aut
700	1	a Brammer, Michael4 aut
700	1	a Brandeis, Daniel4 aut
700	1	a Brogna, Claudia4 aut
700	1	a de Bruijn, Yvette4 aut
700	1	a Chakrabarti, Bhismadev4 aut
700	1	a Cornelissen, Ineke4 aut
700	1	a Acqua, Flavio Dell'4 aut
700	1	a Dumas, Guillaume4 aut
700	1	a Durston, Sarah4 aut
700	1	a Ecker, Christine4 aut
700	1	a Faulkner, Jessica4 aut
700	1	a Frouin, Vincent4 aut
700	1	a Garcés, Pilar4 aut
700	1	a Ham, Lindsay4 aut
700	1	a Hayward, Hannah4 aut
700	1	a Hipp, Joerg4 aut
700	1	a Holt, Rosemary J4 aut
700	1	a Isaksson, Johanu Karolinska Institutet,Uppsala universitet,Barn- och ungdomspsykiatri,Karolinska Inst KIND, Ctr Neurodev Disorders, Stockholm, Sweden4 aut0 (Swepub:uu)johis856
700	1	a Johnson, Mark H4 aut
700	1	a Jones, Emily J H4 aut
700	1	a Kundu, Prantik4 aut
700	1	a Lai, Meng-Chuan4 aut
700	1	a D'ardhuy, Xavier Liogier4 aut
700	1	a Lombardo, Michael V4 aut
700	1	a Lythgoe, David J4 aut
700	1	a Mandl, René4 aut
700	1	a Mason, Luke4 aut
700	1	a Meyer-Lindenberg, Andreas4 aut
700	1	a Moessnang, Carolin4 aut
700	1	a Mueller, Nico4 aut
700	1	a O'Dwyer, Laurence4 aut
700	1	a Oldehinkel, Marianne4 aut
700	1	a Oranje, Bob4 aut
700	1	a Pandina, Gahan4 aut
700	1	a Persico, Antonio M4 aut
700	1	a Ruggeri, Barbara4 aut
700	1	a Ruigrok, Amber N V4 aut
700	1	a Sabet, Jessica4 aut
700	1	a Sacco, Roberto4 aut
700	1	a Cáceres, Antonia San Jóse4 aut
700	1	a Simonoff, Emily4 aut
700	1	a Toro, Roberto4 aut
700	1	a Tost, Heike4 aut
700	1	a Waldman, Jack4 aut
700	1	a Williams, Steve C R4 aut
700	1	a Zwiers, Marcel P4 aut
700	1	a Spooren, Will4 aut
700	1	a Murphy, Declan G M4 aut
700	1	a Buitelaar, Jan K4 aut
710	2	a Karolinska Institutetb Barn- och ungdomspsykiatri4 org
773	0	t Molecular Autismd : Springer Science and Business Media LLCg 8q 8x 2040-2392
856	4	u https://uu.diva-portal.org/smash/get/diva2:1115619/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://doi.org/10.1186/s13229-017-0145-9
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-325672
856	4 8	u https://doi.org/10.1186/s13229-017-0145-9
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:136090653

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Av författaren/redakt...: Charman, Tony; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, Caro ...; Goyard, David; visa fler...; Ahmad, Jumana; Auyeung, Bonnie; Ambrosino, Sara; Banaschewski, To ...; Baron-Cohen, Sim ...; Baumeister, Sara ...; Beckmann, Christ ...; Bölte, Sven; Bourgeron, Thoma ...; Bours, Carsten; Brammer, Michael; Brandeis, Daniel; Brogna, Claudia; de Bruijn, Yvett ...; Chakrabarti, Bhi ...; Cornelissen, Ine ...; Acqua, Flavio De ...; Dumas, Guillaume; Durston, Sarah; Ecker, Christine; Faulkner, Jessic ...; Frouin, Vincent; Garcés, Pilar; Ham, Lindsay; Hayward, Hannah; Hipp, Joerg; Holt, Rosemary J; Isaksson, Johan; Johnson, Mark H; Jones, Emily J H; Kundu, Prantik; Lai, Meng-Chuan; D'ardhuy, Xavier ...; Lombardo, Michae ...; Lythgoe, David J; Mandl, René; Mason, Luke; Meyer-Lindenberg ...; Moessnang, Carol ...; Mueller, Nico; O'Dwyer, Laurenc ...; Oldehinkel, Mari ...; Oranje, Bob; Pandina, Gahan; Persico, Antonio ...; Ruggeri, Barbara; Ruigrok, Amber N ...; Sabet, Jessica; Sacco, Roberto; Cáceres, Antonia ...; Simonoff, Emily; Toro, Roberto; Tost, Heike; Waldman, Jack; Williams, Steve ...; Zwiers, Marcel P; Spooren, Will; Murphy, Declan G ...; Buitelaar, Jan K; visa färre...

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