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Maternal fetal loss...
Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring : a systematic review and meta-analysis
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- Karalexi, M. A. (författare)
- University of Athens
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- Dessypris, N. (författare)
- University of Athens
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- Skalkidou, Alkistis, 1977- (författare)
- Uppsala universitet,Obstetrisk forskning
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- Biniaris-Georgallis, S. -I (författare)
- University of Athens
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- Kalogirou, E. I. (författare)
- University of Athens
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- Thomopoulos, T. P. (författare)
- University of Athens
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- Herlenius, E. (författare)
- Karolinska Institutet
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- Spector, L. G. (författare)
- University of Minnesota
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- Loutradis, D. (författare)
- University of Athens
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- Chrousos, G. P. (författare)
- University of Athens
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- Petridou, E. Th. (författare)
- University of Athens
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(creator_code:org_t)
- 2017-04-11
- 2017
- Engelska.
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Ingår i: Cancer Causes and Control. - : SPRINGER. - 0957-5243 .- 1573-7225. ; 28:6, s. 599-624
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose History of fetal loss including miscarriage and stillbirth has been inconsistently associated with childhood (0-14 years) leukemia in subsequent offspring. A quantitative synthesis of the inconclusive literature by leukemia subtype was therefore conducted. Methods Eligible studies (N = 32) were identified through the screening of over 3500 publications. Random-effects meta-analyses were conducted on the association of miscarriage/stillbirth history with overall (AL; 18,868 cases/35,685 controls), acute lymphoblastic (ALL; 16,150 cases/38,655 controls), and myeloid (AML; 3042 cases/32,997 controls) leukemia. Sensitivity and subgroup analyses by age and ALL subtype, as well as meta-regression were undertaken. Results Fetal loss history was associated with increased AL risk [Odds Ratio (OR) 1.10, 95% Confidence Intervals (CI) 1.04-1.18]. The positive association was seen for ALL (OR 1.12, 95%CI 1.05-1.19) and for AML (OR 1.13, 95%CI 0.91-1.41); for the latter the OR increased in sensitivity analyses. Notably, stillbirth history was significantly linked to ALL risk (OR 1.33, 95%CI 1.02-1.74), but not AML. By contrast, the association of ALL and AML with previous miscarriage reached marginal significance. The association of miscarriage history was strongest in infant ALL (OR 2.34, 95%CI 1.19-4.60). Conclusions In this meta-analysis involving > 50,000 children, we found noteworthy associations by indices of fetal loss, age at diagnosis, and leukemia type; namely, of stillbirth with ALL and miscarriage history with infant ALL. Elucidation of plausible underlying mechanisms may provide insight into leukemia pathogenesis and indicate monitoring interventions prior to and during pregnancy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Miscarriage
- Stillbirth
- Childhood acute lymphoblastic leukemia
- Childhood acute myeloid leukemia
- Meta-analysis
- Meta-regression
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Karalexi, M. A.
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Dessypris, N.
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Skalkidou, Alkis ...
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Biniaris-Georgal ...
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Kalogirou, E. I.
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Thomopoulos, T. ...
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visa fler...
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Herlenius, E.
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Spector, L. G.
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Loutradis, D.
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Chrousos, G. P.
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Petridou, E. Th.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancer Causes an ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet