High expression of cyclin D1 is associated to high proliferation rate and increased risk of mortality in women with ER-positive but not in ER-negative breast cancers

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Ahlin, CeciliaÖrebro University (författare)

High expression of cyclin D1 is associated to high proliferation rate and increased risk of mortality in women with ER-positive but not in ER-negative breast cancers

Artikel/kapitelEngelska2017

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2017-05-20
SPRINGER,2017
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:uu-329916
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329916URI
https://doi.org/10.1007/s10549-017-4294-5DOI
https://lup.lub.lu.se/record/c3220b9d-b86a-4280-a2d8-7f7e257fc64dURI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

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Cyclin D1 has a central role in cell cycle control and is an important component of estrogen regulation of cell cycle progression. We have previously shown that high cyclin D expression is related to aggressive features of ER-positive but not ER-negative breast cancer. The aims of the present study were to validate this differential ER-related effect and furthermore explore the relationship between cyclin D overexpression and CCND1 gene amplification status in a node-negative breast cancer case-control study. Immunohistochemical nuclear expression of cyclin D1 (n = 364) and amplification of the gene CCND1 by fluorescent in situ hybridization (n = 255) was performed on tissue microarray sections from patients with T1-2N0M0 breast cancer. Patients given adjuvant chemotherapy were excluded. The primary event was defined as breast cancer death. Breast cancer-specific survival was analyzed in univariate and multivariable models using conditional logistic regression. Expression of cyclin D1 above the median (61.7%) in ER breast cancer was associated with an increased risk for breast cancer death (OR 3.2 95% CI 1.5-6.8) also when adjusted for tumor size and grade (OR 3.1). No significant prognostic impact of cyclin D1 expression was found among ER-negative cases. Cyclin D1 overexpression was significantly associated to high expression of the proliferation markers cyclins A (rho 0.19, p = 0.006) and B (rho 0.18, p = 0.003) in ER-positive tumors, but not in ER-negative cases. There was a significant association between CCND1 amplification and cyclin D1 expression (p = 0.003), but CCND1 amplification was not statistically significantly prognostic (HR 1.4, 95% CI 0.4-4.4). We confirmed our previous observation that high cyclin D1 expression is associated to high proliferation and a threefold higher risk of death from breast cancer in ER-positive breast cancer.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Breast cancer
Proliferation
Cyclin D1
CCND1
Breast cancer
CCND1
Cyclin D1
Proliferation

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lundgren, Claudia,1966-Uppsala University,Uppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)clalu702 (författare)
Embretsen-Varro, ElinÖrebro University (författare)
Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)pat-kji (författare)
Blomqvist, CarlÖrebro University,University of Helsinki (författare)
Fjällskog, Marie-LouiseUppsala University,Uppsala universitet,Onkologisk endokrinologi(Swepub:uu)marifjal (författare)
Örebro UniversityExperimentell och klinisk onkologi (creator_code:org_t)

Sammanhörande titlar

Ingår i:Breast Cancer Research and Treatment: SPRINGER164:3, s. 667-6780167-68061573-7217

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Breast Cancer Research and Treatment (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Ahlin, Cecilia; Lundgren, Claudi ...; Embretsen-Varro, ...; Jirström, Karin; Blomqvist, Carl; Fjällskog, Marie ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Breast Cancer Re ...

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