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Systematic Analysis...
Systematic Analysis of the Cerebrospinal Fluid Proteome of Fibromyalgia patients
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- Emami Khoonsari, Payam (författare)
- Uppsala universitet,Klinisk kemi
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- Musunri, Sravani (författare)
- Uppsala universitet,Analytisk kemi
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- Herman, Stephanie (författare)
- Uppsala universitet,Klinisk kemi
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- Svensson, Camilla I (författare)
- Karolinska Institutet
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- Tanum, Lars (författare)
- Department of R&D in Mental Health, Akershus University Hospital, Lørenskog, Norway.
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- Gordh, Torsten (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Kultima, Kim (författare)
- Uppsala universitet,Klinisk kemi
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: Journal of Proteomics. - : Elsevier BV. - 1874-3919 .- 1876-7737. ; , s. 35-43
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Fibromyalgia (FM) is a syndrome characterized by widespread muscular pain, fatigue and functional symptoms, which is known to be difficult to diagnose as the various symptoms overlap with many other conditions. Currently, there are no biomarkers for FM, and the diagnosis is made subjectively by the clinicians. We have performed shotgun proteomics on cerebrospinal fluid (CSF) from FM patients and non-pain controls to find potential biomarker candidates for this syndrome. Based on our multivariate and univariate analyses, we found that the relative differences in the CSF proteome between FM patients and controls were moderate. Four proteins, important to discriminate FM patients from non-pain controls, were found: Apolipoprotein C-III, Galectin-3-binding protein, Malate dehydrogenase cytoplasmic and the neuropeptide precursor protein ProSAAS. These proteins are involved in lipoprotein lipase (LPL) activity, inflammatory signaling, energy metabolism and neuropeptide signaling.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Nyckelord
- cerebrospinal fluid
- biomarker
- chronic pain
- fibromyalgia
- inflammation
- neuroinflammation
- mass spectrometry
- Bioinformatik
- Bioinformatics
- Biology with specialization in Molecular Biology
- Biologi med inriktning mot molekylärbiologi
- Kemi med inriktning mot analytisk kemi
- Chemistry with specialization in Analytical Chemistry
- Medicinsk vetenskap
- Medical Science
- Klinisk kemi
- Clinical Chemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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