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Curcumin Suppresses...
Curcumin Suppresses Tumor Growth and Angiogenesis in Human Glioma Cells Through Modulation of Vascular Endothelial Growth Factor/Angiopoietin-2/Thrombospondin-1 Signaling
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- Zhang, Zhiqiang (författare)
- Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China.
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- Li, Cong (författare)
- Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China.
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- Tan, Qijia (författare)
- Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China.
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- Xie, Caijun (författare)
- Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China.
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- Yang, Yanying (författare)
- Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China.
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- Zhan, Wengang (författare)
- Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China.
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- Han, Fu (författare)
- Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China.
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- Sharma, Hari Shanker (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Sharma, Aruna (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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Univ Chinese Med Guangzhou, Affiliated Hosp 2, Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Guangdong, Peoples R China Anestesiologi och intensivvård (creator_code:org_t)
- Bentham Science Publishers Ltd. 2017
- 2017
- Engelska.
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Ingår i: CNS & Neurological Disorders. - : Bentham Science Publishers Ltd.. - 1871-5273 .- 1996-3181. ; 16:3, s. 346-350
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Purpose: To investigate the effect of curcumin on tumor growth and angiogenesis of human gliomas and identify the underlying molecular mechanisms. Methods: A mouse xenograft glioma model was established by subcutaneously inoculating tumor cell aggregates derived from the U87 cell line. Mice were treated with 0.01ml/g body weight of curcumin or saline. Tumor volume was measured. Microvessel density was assessed by CD34 immunostaining, and angiogenesis by immunohistochemical staining of vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2) and thrombospondin 1 (TSP-1). Results: At 28 days after treatment, tumor weights in the curcumin-treated group were much smaller than in the control group (0.23 +/- 0.11g vs. 0.44 +/- 0.15g p < 0.05), resulting in a 45.8% inhibition of tumor growth. Curcumin also markedly inhibited microvessel density. Expression of VEGF and Ang-2 was inhibited by curcumin, whereas TSP-1 expression was up-regulated. Conclusion: This study shows that curcumin inhibits tumor growth by inhibiting VEGF/Ang-2/TSP-1-mediated angiogenesis in a xenograft glioma mouse model.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Curcumin
- glioma
- angiogenesis
- vascular endothelial growth factor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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