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The BEACH Protein L...
The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia
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- Kurtenbach, Stefan (författare)
- Ruhr Univ Bochum, Dept Cell Physiol, D-44780 Bochum, Germany.
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- Giessl, Andreas (författare)
- Univ Erlangen Nurnberg, Dept Biol, Anim Physiol, D-91058 Erlangen, Germany.
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- Strömberg, Siv (författare)
- Uppsala universitet,Molekylär cellbiologi
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- Kremers, Jan (författare)
- Univ Hosp Erlangen, Dept Ophthalmol, D-91054 Erlangen, Germany.;Friedrich Alexander Univ Erlangen Nurnberg, Dept Anat 2, D-91054 Erlangen, Germany.
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- Atorf, Jenny (författare)
- Univ Hosp Erlangen, Dept Ophthalmol, D-91054 Erlangen, Germany.
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- Rasche, Sebastian (författare)
- Ruhr Univ Bochum, Dept Cell Physiol, D-44780 Bochum, Germany.
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- Neuhaus, Eva M. (författare)
- Univ Hosp Jena, Dept Pharmacol & Toxikol, D-07747 Jena, Germany.
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- Herve, Denis (författare)
- Univ Paris 06, Inst Fer Moulin, INSERM, UMR S839, F-75005 Paris, France.
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- Brandstaetter, Johann Helmut (författare)
- Univ Erlangen Nurnberg, Dept Biol, Anim Physiol, D-91058 Erlangen, Germany.
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- Asan, Esther (författare)
- Univ Wurzburg, Inst Anat & Cell Biol, D-97070 Wurzburg, Germany.
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- Hatt, Hanns (författare)
- Ruhr Univ Bochum, Dept Cell Physiol, D-44780 Bochum, Germany.
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- Kilimann, Manfred W (författare)
- Uppsala universitet,Molekylär cellbiologi,Max Planck Inst Expt Med, Dept Mol Neurobiol, Gottingen, Germany
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Ruhr Univ Bochum, Dept Cell Physiol, D-44780 Bochum, Germany Univ Erlangen Nurnberg, Dept Biol, Anim Physiol, D-91058 Erlangen, Germany. (creator_code:org_t)
- 2017-08-16
- 2017
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BEACH domain proteins are involved in membrane protein traffic and human diseases, but their molecular mechanisms are not understood. The BEACH protein LRBA has been implicated in immune response and cell proliferation, and human LRBA mutations cause severe immune deficiency. Here, we report a first functional and molecular phenotype outside the immune system of LRBA-knockout mice: compromised olfaction, manifesting in reduced electro-olfactogram response amplitude, impaired food-finding efficiency, and smaller olfactory bulbs. LRBA is prominently expressed in olfactory and vomeronasal chemosensory neurons of wild-type mice. Olfactory impairment in the LRBA-KO is explained by markedly reduced concentrations (20-40% of wild-type levels) of all three subunits alpha(olf), beta(1) and gamma(13) of the olfactory heterotrimeric G-protein, G(olf), in the sensory cilia of olfactory neurons. In contrast, cilia morphology and the concentrations of many other proteins of olfactory cilia are not or only slightly affected. LRBA is also highly expressed in photoreceptor cells, another cell type with a specialized sensory cilium and heterotrimeric G-protein-based signalling; however, visual function appeared unimpaired by the LRBA-KO. To our knowledge, this is the first observation that a BEACH protein is required for the efficient subcellular localization of a lipid-anchored protein, and of a ciliary protein.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Kurtenbach, Stef ...
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Giessl, Andreas
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Strömberg, Siv
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Kremers, Jan
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Atorf, Jenny
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Rasche, Sebastia ...
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visa fler...
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Neuhaus, Eva M.
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Herve, Denis
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Brandstaetter, J ...
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Asan, Esther
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Hatt, Hanns
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Kilimann, Manfre ...
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visa färre...
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