Sökning: onr:"swepub:oai:DiVA.org:uu-333782" >
Visualization of pa...
Visualization of painful inflammation in patients with pain after traumatic ankle sprain using [(11)C]-D-deprenyl PET/CT.
-
- Aarnio, Mikko (författare)
- Uppsala universitet,Anestesiologi och intensivvård
-
- Appel, Lieuwe (författare)
- Uppsala universitet,Radiologi
-
- Fredriksson, Mats (författare)
- Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden
-
visa fler...
-
- Gordh, Torsten (författare)
- Uppsala universitet,Anestesiologi och intensivvård
-
- Wolf, Olof (författare)
- Uppsala universitet,Ortopedi
-
- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi
-
- Eriksson, Måns, 1986- (författare)
- Uppsala universitet,Statistiska institutionen
-
- Peterson, Magnus, 1966- (författare)
- Uppsala universitet,Allmänmedicin och preventivmedicin
-
- Linnman, Clas (författare)
- Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol, Boston, MA USA
-
Thulin, M (författare)
-
visa färre...
-
(creator_code:org_t)
- Walter de Gruyter, 2017
- 2017
- Engelska.
-
Ingår i: Scandinavian Journal of Pain. - : Walter de Gruyter. - 1877-8860 .- 1877-8879. ; 17:1, s. 418-424
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND AND AIMS: Positron emission tomography (PET) with the radioligand [(11)C]-D-deprenyl has shown increased signal at location of pain in patients with rheumatoid arthritis and chronic whiplash injury. The binding site of [(11)C]-D-deprenyl in peripheral tissues is suggested to be mitochondrial monoamine oxidase in cells engaged in post-traumatic inflammation and tissue repair processes. The association between [(11)C]-D-deprenyl uptake and the transition from acute to chronic pain remain unknown. Further imaging studies of musculoskeletal pain at the molecular level would benefit from establishing a clinical model in a common and well-defined injury in otherwise healthy and drug-naïve subjects. The aim of this study was to investigate if [(11)C]-D-deprenyl uptake would be acutely elevated in unilateral ankle sprain and if tracer uptake would be reduced as a function of healing, and correlated with pain localizations and pain experience.METHODS: Eight otherwise healthy patients with unilateral ankle sprain were recruited at the emergency department. All underwent [(11)C]-D-deprenyl PET/CT in the acute phase, at one month and 6-14 months after injury.RESULTS: Acute [(11)C]-D-deprenyl uptake at the injury site was a factor of 10.7 (range 2.9-37.3) higher than the intact ankle. During healing, [(11)C]-D-deprenyl uptake decreased, but did not normalize until after 11 months. Patients experiencing persistent pain had prolonged [(11)C]-D-deprenyl uptake in painful locations.CONCLUSIONS AND IMPLICATIONS: The data provide further support that [(11)C]-D-deprenyl PET can visualize, quantify and follow processes in peripheral tissue that may relate to soft tissue injuries, inflammation and associated nociceptive signaling. Such an objective correlate would represent a progress in pain research, as well as in clinical pain diagnostics and management.
Nyckelord
- Ankle injuries
- Carbon-11
- Deprenyl
- Inflammation
- PET
- Pain
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Aarnio, Mikko
-
Appel, Lieuwe
-
Fredriksson, Mat ...
-
Gordh, Torsten
-
Wolf, Olof
-
Sörensen, Jens
-
visa fler...
-
Eriksson, Måns, ...
-
Peterson, Magnus ...
-
Linnman, Clas
-
Thulin, M
-
visa färre...
- Artiklar i publikationen
-
Scandinavian Jou ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet