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Nanoparticle-loaded...
Nanoparticle-loaded Hydrogels as a Pathway for Enzyme-triggered Drug Release in Ophthalmic Applications
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- Åhlén, Michelle (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Tummala, Gopi Krishna, 1986- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Mihranyan, Albert, 1978- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- Engelska.
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Ingår i: International Journal of Pharmaceutics. - : Elsevier. - 0378-5173 .- 1873-3476. ; 536:1, s. 73-81
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study was to develop nanoparticle loaded hydrogel based contact lenses that could be used for ocular drug delivery. Two potential contact lens platforms for controlled ophthalmic drug delivery were developed by incorporating chitosan-poly(acrylic acid) nanoparticles into polyvinyl alcohol (PVA) hydrogels and in-situ gelled nanoparticles and cellulose nanocrystals (CNC) in PVA lenses. The nanoparticles were shown to disintegrate in a physiological 0.2 mM concentration of lysozyme resulting from the hydrolysis of the chitosan chains by lysozyme. An extended release over a 28-hour period was demonstrated once the nanoparticles had been integrated into the composite lenses, with nanoparticle-CNC PVA lenses showing even greater potential for extended release. The platform shows great promise in developing enzyme-triggered ocular drug delivery systems.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Nyckelord
- Nanoparticles
- PVA
- Chitosan
- Drug delivery
- Ophthalmic
- Engineering Science with specialization in Nanotechnology and Functional Materials
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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