Sökning: onr:"swepub:oai:DiVA.org:uu-335243" >
CTCF counter-regula...
CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart
-
- Gomez-Velazquez, Melisa (författare)
- CNIC, Madrid, Spain.
-
- Badia-Careaga, Claudio (författare)
- CNIC, Madrid, Spain.
-
- Victoria Lechuga-Vieco, Ana (författare)
- CNIC, Madrid, Spain.
-
visa fler...
-
- Nieto-Arellano, Rocio (författare)
- CNIC, Madrid, Spain.
-
- Tena, Juan J. (författare)
- Univ Pablo de Olavide Junta de Andalucia, CSIC, CABD, Seville, Spain.
-
- Rollan, Isabel (författare)
- CNIC, Madrid, Spain.
-
- Alvarez, Alba (författare)
- CNIC, Madrid, Spain.
-
- Torroja, Carlos (författare)
- CNIC, Madrid, Spain.
-
- Caceres, Eva F. (författare)
- Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab,CNIC, Madrid, Spain.
-
- Roy, Anna (författare)
- Hosp Sick Children, Translat Med, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.
-
- Galjart, Niels (författare)
- Erasmus MC, Dept Cell Biol & Genet, Rotterdam, Netherlands.
-
- Delgado-Olguin, Paul (författare)
- Hosp Sick Children, Translat Med, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.;Heart & Stroke Richard Lewar Ctr Excellence, Toronto, ON, Canada.
-
- Sanchez-Cabo, Fatima (författare)
- CNIC, Madrid, Spain.
-
- Antonio Enriquez, Jose (författare)
- CNIC, Madrid, Spain.
-
- Luis Gomez-Skarmeta, Jose (författare)
- Univ Pablo de Olavide Junta de Andalucia, CSIC, CABD, Seville, Spain.
-
- Manzanares, Miguel (författare)
- CNIC, Madrid, Spain.
-
visa färre...
-
CNIC, Madrid, Spain Univ Pablo de Olavide Junta de Andalucia, CSIC, CABD, Seville, Spain. (creator_code:org_t)
- 2017-08-28
- 2017
- Engelska.
-
Ingår i: PLOS Genetics. - : PUBLIC LIBRARY SCIENCE. - 1553-7390 .- 1553-7404. ; 13:8
- Relaterad länk:
-
https://uu.diva-port... (primary) (Raw object)
-
visa fler...
-
https://journals.plo...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Cardiac progenitors are specified early in development and progressively differentiate and mature into fully functional cardiomyocytes. This process is controlled by an extensively studied transcriptional program. However, the regulatory events coordinating the progression of such program from development to maturation are largely unknown. Here, we show that the genome organizer CTCF is essential for cardiogenesis and that it mediates genomic interactions to coordinate cardiomyocyte differentiation and maturation in the developing heart. Inactivation of Ctcf in cardiac progenitor cells and their derivatives in vivo during development caused severe cardiac defects and death at embryonic day 12.5. Genome wide expression analysis in Ctcf mutant hearts revealed that genes controlling mitochondrial function and protein production, required for cardiomyocyte maturation, were upregulated. However, mitochondria from mutant cardiomyocytes do not mature properly. In contrast, multiple development regulatory genes near predicted heart enhancers, including genes in the IrxA cluster, were downregulated in Ctcf mutants, suggesting that CTCF promotes cardiomyocyte differentiation by facilitating enhancer-promoter interactions. Accordingly, loss of CTCF disrupts gene expression and chromatin interactions as shown by chromatin conformation capture followed by deep sequencing. Furthermore, CRISPR-mediated deletion of an intergenic CTCF site within the IrxA cluster alters gene expression in the developing heart. Thus, CTCF mediates local regulatory interactions to coordinate transcriptional programs controlling transitions in morphology and function during heart development.
Ämnesord
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Gomez-Velazquez, ...
-
Badia-Careaga, C ...
-
Victoria Lechuga ...
-
Nieto-Arellano, ...
-
Tena, Juan J.
-
Rollan, Isabel
-
visa fler...
-
Alvarez, Alba
-
Torroja, Carlos
-
Caceres, Eva F.
-
Roy, Anna
-
Galjart, Niels
-
Delgado-Olguin, ...
-
Sanchez-Cabo, Fa ...
-
Antonio Enriquez ...
-
Luis Gomez-Skarm ...
-
Manzanares, Migu ...
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Utvecklingsbiolo ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
PLOS Genetics
- Av lärosätet
-
Uppsala universitet