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Practice patterns o...
Practice patterns of palliative radiation therapy in pediatric oncology patients in an international pediatric research consortium
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- Rao, Avani Dholakia (författare)
- Johns Hopkins Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA.
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- Chen, Qinyu (författare)
- Johns Hopkins Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA.
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- Ermoian, Ralph P. (författare)
- Univ Washington, Dept Radiat Oncol, Seattle, WA 98195 USA.
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- Alcorn, Sara R. (författare)
- Johns Hopkins Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA.
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- Figueiredo, Maria Luisa S. (författare)
- Grp Apoio Adolescente & Crianca Canc, Dept Radiat, Sao Paulo, Brazil.
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- Chen, Michael J. (författare)
- Grp Apoio Adolescente & Crianca Canc, Dept Radiat, Sao Paulo, Brazil.
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- Dieckmann, Karin (författare)
- Univ Klin Strahlentherapie & Strahlenbiol, Dept Radiat Oncol, Vienna, Austria.
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- MacDonald, Shannon M. (författare)
- Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA.
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- Ladra, Matthew M. (författare)
- Johns Hopkins Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA.
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- Kobyzeva, Daria (författare)
- Fed Sci Clin Ctr Childrens Hematol Oncol & Immuno, Dept Radiotherapy, Moscow, Russia.
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- Nechesnyuk, Alexey V. (författare)
- Fed Sci Clin Ctr Childrens Hematol Oncol & Immuno, Dept Radiotherapy, Moscow, Russia.
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- Nilsson, Kristina, 1967- (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Ford, Eric C. (författare)
- Univ Washington, Dept Radiat Oncol, Seattle, WA 98195 USA.
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- Winey, Brian A. (författare)
- Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA.
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- Villar, Rosangela C. (författare)
- Ctr Infantil Boldrini, Dept Radiat Oncol, Sao Paulo, Brazil.;Ctr Infantil Boldrini, Dept Radiat Oncol, Regiao, Brazil.
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- Terezakis, Stephanie A. (författare)
- Johns Hopkins Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA.
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Johns Hopkins Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA Univ Washington, Dept Radiat Oncol, Seattle, WA 98195 USA. (creator_code:org_t)
- 2017-07-11
- 2017
- Engelska.
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Ingår i: Pediatric Blood & Cancer. - : Wiley. - 1545-5009 .- 1545-5017. ; 64:11
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background/Objectives:The practice of palliative radiation therapy (RT) is based on extrapolation from adult literature. We evaluated patterns of pediatric palliative RT to describe regimens used to identify opportunity for future pediatric-specific clinical trials.Design/Methods:Six international institutions with pediatric expertise completed a 122-item survey evaluating patterns of palliative RT for patients 21 years old from 2010 to 2015. Two institutions use proton RT. Palliative RT was defined as treatment with the goal of symptom control or prevention of immediate life-threatening progression.Results:Of 3,225 pediatric patients, 365 (11%) were treated with palliative intent to a total of 427 disease sites. Anesthesia was required in 10% of patients. Treatment was delivered to metastatic disease in 54% of patients. Histologies included neuroblastoma (30%), osteosarcoma (18%), leukemia/lymphoma (12%), rhabdomyosarcoma (12%), medulloblastoma/ependymoma (12%), Ewing sarcoma (8%), and other (8%). Indications included pain (43%), intracranial symptoms (23%), respiratory compromise (14%), cord compression (8%), and abdominal distention (6%). Sites included nonspine bone (35%), brain (16% primary tumors, 6% metastases), abdomen/pelvis (15%), spine (12%), head/neck (9%), and lung/mediastinum (5%). Re-irradiation comprised 16% of cases. Techniques employed three-dimensional conformal RT (41%), intensity-modulated RT (23%), conventional RT (26%), stereotactic body RT (6%), protons (1%), electrons (1%), and other (2%). The most common physician-reported barrier to consideration of palliative RT was the concern about treatment toxicity (83%).Conclusion:There is significant diversity of practice in pediatric palliative RT. Combined with ongoing research characterizing treatment response and toxicity, these data will inform the design of forthcoming clinical trials to establish effective regimens and minimize treatment toxicity for this patient population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- palliative radiation therapy
- palliative therapy
- pediatric radiation therapy
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- Av författaren/redakt...
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Rao, Avani Dhola ...
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Chen, Qinyu
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Ermoian, Ralph P ...
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Alcorn, Sara R.
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Figueiredo, Mari ...
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Chen, Michael J.
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Dieckmann, Karin
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MacDonald, Shann ...
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Ladra, Matthew M ...
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Kobyzeva, Daria
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Nechesnyuk, Alex ...
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Nilsson, Kristin ...
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Ford, Eric C.
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Winey, Brian A.
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Villar, Rosangel ...
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Terezakis, Steph ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Pediatrik
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Uppsala universitet