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Circulating Folate ...
Circulating Folate and Vitamin B12 and Risk of Prostate Cancer : A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls.
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Price, Alison J (författare)
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Travis, Ruth C (författare)
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Appleby, Paul N (författare)
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visa fler...
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Albanes, Demetrius (författare)
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Barricarte Gurrea, Aurelio (författare)
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Bjørge, Tone (författare)
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Bueno-de-Mesquita, H Bas (författare)
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Chen, Chu (författare)
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Donovan, Jenny (författare)
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Gislefoss, Randi (författare)
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Goodman, Gary (författare)
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Gunter, Marc (författare)
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Hamdy, Freddie C (författare)
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- Johansson, Mattias (författare)
- Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, Lyon, France
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King, Irena B (författare)
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Kühn, Tilman (författare)
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Männistö, Satu (författare)
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Martin, Richard M (författare)
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Meyer, Klaus (författare)
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Neal, David E (författare)
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Neuhouser, Marian L (författare)
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Nygård, Ottar (författare)
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- Stattin, Pär (författare)
- Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi
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Tell, Grethe S (författare)
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Trichopoulou, Antonia (författare)
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Tumino, Rosario (författare)
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Ueland, Per Magne (författare)
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Ulvik, Arve (författare)
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de Vogel, Stefan (författare)
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Vollset, Stein Emil (författare)
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Weinstein, Stephanie J (författare)
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Key, Timothy J (författare)
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Allen, Naomi E (författare)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 70:6, s. 941-951
- Relaterad länk:
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http://www.europeanu...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Folate and vitamin B12 are essential for maintaining DNA integrity and may influence prostate cancer (PCa) risk, but the association with clinically relevant, advanced stage, and high-grade disease is unclear.OBJECTIVE: To investigate the associations between circulating folate and vitamin B12 concentrations and risk of PCa overall and by disease stage and grade.DESIGN, SETTING, AND PARTICIPANTS: A study was performed with a nested case-control design based on individual participant data from six cohort studies including 6875 cases and 8104 controls; blood collection from 1981 to 2008, and an average follow-up of 8.9 yr (standard deviation 7.3). Odds ratios (ORs) of incident PCa by study-specific fifths of circulating folate and vitamin B12 were calculated using multivariable adjusted conditional logistic regression.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Incident PCa and subtype by stage and grade.RESULTS AND LIMITATIONS: Higher folate and vitamin B12 concentrations were associated with a small increase in risk of PCa (ORs for the top vs bottom fifths were 1.13 [95% confidence interval (CI), 1.02-1.26], ptrend=0.018, for folate and 1.12 [95% CI, 1.01-1.25], ptrend=0.017, for vitamin B12), with no evidence of heterogeneity between studies. The association with folate varied by tumour grade (pheterogeneity<0.001); higher folate concentration was associated with an elevated risk of high-grade disease (OR for the top vs bottom fifth: 2.30 [95% CI, 1.28-4.12]; ptrend=0.001), with no association for low-grade disease. There was no evidence of heterogeneity in the association of folate with risk by stage or of vitamin B12 with risk by stage or grade of disease (pheterogeneity>0.05). Use of single blood-sample measurements of folate and B12 concentrations is a limitation.CONCLUSIONS: The association between higher folate concentration and risk of high-grade disease, not evident for low-grade disease, suggests a possible role for folate in the progression of clinically relevant PCa and warrants further investigation.PATIENT SUMMARY: Folate, a vitamin obtained from foods and supplements, is important for maintaining cell health. In this study, however, men with higher blood folate levels were at greater risk of high-grade (more aggressive) prostate cancer compared with men with lower folate levels. Further research is needed to investigate the possible role of folate in the progression of this disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Folate
- High grade
- Pooled data meta-analysis
- Prospective cohort
- Prostate cancer
- Vitamin B(12)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Price, Alison J
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Travis, Ruth C
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Appleby, Paul N
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Albanes, Demetri ...
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Barricarte Gurre ...
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Bjørge, Tone
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visa fler...
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Bueno-de-Mesquit ...
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Chen, Chu
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Donovan, Jenny
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Gislefoss, Randi
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Goodman, Gary
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Gunter, Marc
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Hamdy, Freddie C
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Johansson, Matti ...
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King, Irena B
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Kühn, Tilman
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Männistö, Satu
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Martin, Richard ...
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Meyer, Klaus
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Neal, David E
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Neuhouser, Maria ...
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Nygård, Ottar
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Stattin, Pär
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Tell, Grethe S
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Trichopoulou, An ...
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Tumino, Rosario
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Ueland, Per Magn ...
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Ulvik, Arve
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de Vogel, Stefan
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Vollset, Stein E ...
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Weinstein, Steph ...
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Key, Timothy J
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Allen, Naomi E
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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European Urology
- Av lärosätet
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Uppsala universitet
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Umeå universitet