Sökning: onr:"swepub:oai:DiVA.org:uu-336327" > Circulating Folate ...
Fältnamn | Indikatorer | Metadata |
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000 | 05826naa a2200805 4500 | |
001 | oai:DiVA.org:uu-336327 | |
003 | SwePub | |
008 | 171213s2016 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-122122 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3363272 URI |
024 | 7 | a https://doi.org/10.1016/j.eururo.2016.03.0292 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1221222 URI |
040 | a (SwePub)uud (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Price, Alison J4 aut |
245 | 1 0 | a Circulating Folate and Vitamin B12 and Risk of Prostate Cancer :b A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls. |
264 | 1 | b Elsevier BV,c 2016 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND: Folate and vitamin B12 are essential for maintaining DNA integrity and may influence prostate cancer (PCa) risk, but the association with clinically relevant, advanced stage, and high-grade disease is unclear.OBJECTIVE: To investigate the associations between circulating folate and vitamin B12 concentrations and risk of PCa overall and by disease stage and grade.DESIGN, SETTING, AND PARTICIPANTS: A study was performed with a nested case-control design based on individual participant data from six cohort studies including 6875 cases and 8104 controls; blood collection from 1981 to 2008, and an average follow-up of 8.9 yr (standard deviation 7.3). Odds ratios (ORs) of incident PCa by study-specific fifths of circulating folate and vitamin B12 were calculated using multivariable adjusted conditional logistic regression.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Incident PCa and subtype by stage and grade.RESULTS AND LIMITATIONS: Higher folate and vitamin B12 concentrations were associated with a small increase in risk of PCa (ORs for the top vs bottom fifths were 1.13 [95% confidence interval (CI), 1.02-1.26], ptrend=0.018, for folate and 1.12 [95% CI, 1.01-1.25], ptrend=0.017, for vitamin B12), with no evidence of heterogeneity between studies. The association with folate varied by tumour grade (pheterogeneity<0.001); higher folate concentration was associated with an elevated risk of high-grade disease (OR for the top vs bottom fifth: 2.30 [95% CI, 1.28-4.12]; ptrend=0.001), with no association for low-grade disease. There was no evidence of heterogeneity in the association of folate with risk by stage or of vitamin B12 with risk by stage or grade of disease (pheterogeneity>0.05). Use of single blood-sample measurements of folate and B12 concentrations is a limitation.CONCLUSIONS: The association between higher folate concentration and risk of high-grade disease, not evident for low-grade disease, suggests a possible role for folate in the progression of clinically relevant PCa and warrants further investigation.PATIENT SUMMARY: Folate, a vitamin obtained from foods and supplements, is important for maintaining cell health. In this study, however, men with higher blood folate levels were at greater risk of high-grade (more aggressive) prostate cancer compared with men with lower folate levels. Further research is needed to investigate the possible role of folate in the progression of this disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
653 | a Folate | |
653 | a High grade | |
653 | a Pooled data meta-analysis | |
653 | a Prospective cohort | |
653 | a Prostate cancer | |
653 | a Vitamin B(12) | |
700 | 1 | a Travis, Ruth C4 aut |
700 | 1 | a Appleby, Paul N4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Barricarte Gurrea, Aurelio4 aut |
700 | 1 | a Bjørge, Tone4 aut |
700 | 1 | a Bueno-de-Mesquita, H Bas4 aut |
700 | 1 | a Chen, Chu4 aut |
700 | 1 | a Donovan, Jenny4 aut |
700 | 1 | a Gislefoss, Randi4 aut |
700 | 1 | a Goodman, Gary4 aut |
700 | 1 | a Gunter, Marc4 aut |
700 | 1 | a Hamdy, Freddie C4 aut |
700 | 1 | a Johansson, Mattiasu Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, Lyon, France4 aut0 (Swepub:umu)masmas97 |
700 | 1 | a King, Irena B4 aut |
700 | 1 | a Kühn, Tilman4 aut |
700 | 1 | a Männistö, Satu4 aut |
700 | 1 | a Martin, Richard M4 aut |
700 | 1 | a Meyer, Klaus4 aut |
700 | 1 | a Neal, David E4 aut |
700 | 1 | a Neuhouser, Marian L4 aut |
700 | 1 | a Nygård, Ottar4 aut |
700 | 1 | a Stattin, Päru Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi4 aut0 (Swepub:umu)past0003 |
700 | 1 | a Tell, Grethe S4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Ueland, Per Magne4 aut |
700 | 1 | a Ulvik, Arve4 aut |
700 | 1 | a de Vogel, Stefan4 aut |
700 | 1 | a Vollset, Stein Emil4 aut |
700 | 1 | a Weinstein, Stephanie J4 aut |
700 | 1 | a Key, Timothy J4 aut |
700 | 1 | a Allen, Naomi E4 aut |
710 | 2 | a Umeå universitetb Enheten för biobanksforskning4 org |
773 | 0 | t European Urologyd : Elsevier BVg 70:6, s. 941-951q 70:6<941-951x 0302-2838x 1873-7560 |
856 | 4 | u http://www.europeanurology.com/article/S0302283816003791/pdf |
856 | 4 | u https://doi.org/10.1016/j.eururo.2016.03.029y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:937401/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336327 |
856 | 4 8 | u https://doi.org/10.1016/j.eururo.2016.03.029 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122122 |
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