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Sökning: onr:"swepub:oai:DiVA.org:uu-337077" > Visit-to-visit vari...

Visit-to-visit variability of blood pressure and cardiovascular outcomes in patients with stable coronary heart disease. Insights from the STABILITY trial

Vidal-Petiot, Emmanuelle (författare)
Hop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, Cardiol Dept, 46 Rue Henri Huchard, F-75018 Paris, France.;Hop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, Dept Physiol, 46 Rue Henri Huchard, F-75018 Paris, France.;Paris Diderot Univ, Sorbonne Paris Cite, Paris, France.;INSERM, U1149, Paris, France.
Stebbins, Amanda (författare)
Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.
Chiswell, Karen (författare)
Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.
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Ardissino, Diego (författare)
Univ Parma, Azienda Osped, Via Gramsci 14, I-43126 Parma, Italy.
Aylward, Philip E. (författare)
Flinders Univ & Med Ctr, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia.
Cannon, Christopher P. (författare)
Brigham & Womens Hosp, Cardiovasc Div, 70 Francis St, Boston, MA 02115 USA.;Harvard Clin Res Inst, Boston, MA USA.
Corrales, Marco A. Ramos (författare)
San Jose Satelite Hosp, Circunvalac Poniente 53, Naucalpan De Juarez 53100, Mexico.
Held, Claes, 1956- (författare)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
Lopez-Sendon, Jose Luis (författare)
Hosp Univ La Paz, IdiPaz, Paseo Castellana 261,Planta 1, Madrid 28046, Spain.
Stewart, Ralph A. H. (författare)
Univ Auckland, Auckland City Hosp, Green Lane Cardiovasc Serv, Private Bag 92024, Auckland 1030, New Zealand.
Wallentin, Lars, 1943- (författare)
Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
White, Harvey D. (författare)
Univ Auckland, Auckland City Hosp, Green Lane Cardiovasc Serv, Private Bag 92024, Auckland 1030, New Zealand.
Steg, Philippe Gabriel (författare)
Hop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, Cardiol Dept, 46 Rue Henri Huchard, F-75018 Paris, France.;Hop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, Dept Physiol, 46 Rue Henri Huchard, F-75018 Paris, France.;Paris Diderot Univ, Sorbonne Paris Cite, Paris, France.;NHLI Imperial Coll, ICMS, Royal Brompton Hosp, London, England.;FACT, F CRIN Network, INSERM, U1148, Paris, France.
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Hop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, Cardiol Dept, 46 Rue Henri Huchard, F-75018 Paris, France;Hop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, Dept Physiol, 46 Rue Henri Huchard, F-75018 Paris, France.;Paris Diderot Univ, Sorbonne Paris Cite, Paris, France.;INSERM, U1149, Paris, France. Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA. (creator_code:org_t)
2017-05-27
2017
Engelska.
Ingår i: European Heart Journal. - : OXFORD UNIV PRESS. - 0195-668X .- 1522-9645. ; 38:37, s. 2813-2822
Relaterad länk:
https://academic.oup...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aims To study the relation between visit-to-visit variability of blood pressure (BP) and cardiovascular risk in patients with stable coronary heart disease. Methods and results In 15 828 patients from the STABILITY trial (darapladib vs. placebo in patients with established coronary heart disease), BP variability was assessed by the standard deviation (SD) of systolic BP, the SD of diastolic BP, maximum BP, and minimum BP, from 5 measurements (baseline and months 1, 3, 6, and 12) during the first year after randomisation. Mean (SD) average BP during the first year of study was 131.0 (13.7) mmHg over 78.3 (8.3) mmHg. Mean (SD) of the visit-to-visit SD was 9.8 (4.8) mmHg for systolic and 6.3 (3.0) mmHg for diastolic BP. During the subsequent median follow-up of 2.6 years, 1010 patients met the primary endpoint, a composite of time to cardiovascular death, myocardial infarction, or stroke. In Cox regression models adjusted for average BP during first year of study, baseline vascular disease, treatment, renal function and cardiovascular risk factors, the primary endpoint was associated with SD of systolic BP (hazard ratio for highest vs. lowest tertile, 1.30, 95% CI 1.10-1.53, P = 0.007), and with SD of diastolic BP (hazard ratio for highest vs. lowest tertile, 1.38, 95% CI 1.18-1.62, P < 0.001). Peaks and troughs in BP were also independently associated with adverse events. Conclusion In patients with stable coronary heart disease, higher visit-to-visit variabilities of both systolic and diastolic BP are strong predictors of increased risk of cardiovascular events, independently of mean BP.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

STABILITY trial
Visit-to-visit variability of blood pressure
Coronary heart disease

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