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Early stages in the...
Early stages in the ontogeny of small B-cell lymphomas : genetics and microenvironment
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- Ghia, P. (författare)
- Univ Vita Salute San Raffaele, Div Expt Oncol, Milan, Italy.;IRCCS San Raffaele Sci Inst Milan, Milan, Italy.
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- Nadel, B. (författare)
- Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France.
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- Sander, B. (författare)
- Karolinska Institutet
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- Stamatopoulos, Kostas (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece
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- Stevenson, F. K. (författare)
- Univ Southampton, Canc Res UK Ctr, Canc Sci Unit, Fac Med,Southampton Gen Hosp, Southampton, Hants, England.
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Univ Vita Salute San Raffaele, Div Expt Oncol, Milan, Italy;IRCCS San Raffaele Sci Inst Milan, Milan, Italy. Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France. (creator_code:org_t)
- 2017-04-10
- 2017
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 282:5, s. 395-414
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- In this review, we focus on the mechanisms underlying lymphomagenesis in chronic lymphocytic leukaemia, follicular lymphoma, mantle cell lymphoma and splenic marginal zone lymphoma. The cells of origin of these small B-cell lymphomas are distinct, as are the characteristic chromosomal lesions and clinical courses. One shared feature is retention of expression of surface immunoglobulin. Analysis of this critical receptor reveals the point of differentiation reached by the cell of origin. Additionally, the sequence patterns of the immunoglobulin-variable domains can indicate a role for stimulants of the B-cell receptor before, during and after malignant transformation. The pathways driven via the B-cell receptor are now being targeted by specific kinase inhibitors with exciting clinical effects. To consider routes to pathogenesis, potentially offering earlier intervention, or to identify causative factors, genetic tools are being used to track pretransformation events and the early phases in lymphomagenesis. These methods are revealing that chromosomal changes are only one of the many steps involved, and that the influence of surrounding cells, probably multiple and variable according to tissue location, is required, both to establish tumours and to maintain growth and survival. Similarly, the influence of the tumour microenvironment may protect malignant cells from eradication by treatment, and the resulting minimal residual disease will eventually give rise to relapse. The common and different features of the four lymphomas will be summarized to show how normal B lymphocytes can be subverted to generate tumours, how these tumours evolve and how their weaknesses can be attacked by targeted therapies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- chronic lymphocytic leukaemia
- follicular lymphoma
- lymphomagenesis
- mantle cell lymphoma
- microenvironment
- splenic marginal zone lymphoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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