Sökning: onr:"swepub:oai:DiVA.org:uu-341488" > The stimulation of ...
Fältnamn | Indikatorer | Metadata |
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000 | 05551naa a2200529 4500 | |
001 | oai:DiVA.org:uu-341488 | |
003 | SwePub | |
008 | 180228s2018 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-144245 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3414882 URI |
024 | 7 | a https://doi.org/10.1039/c7nr07736j2 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1442452 URI |
040 | a (SwePub)uud (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Shrestha, Nehau Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium4 aut |
245 | 1 0 | a The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers |
264 | c 2018 | |
264 | 1 | b Royal Society of Chemistry (RSC),c 2018 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|European Union Seventh Framework Programme (FP7) [281035]; Marie Sklodowska-Curie actions-Standard European fellowship [751257]; FNRS [J.0220.16] | |
520 | a Nanoparticulate based drug delivery systems have been extensively studied to efficiently encapsulate and deliver peptides orally. However, most of the existing data mainly focus on the nanoparticles as a drug carrier, but the ability of nanoparticles having a biological effect has not been exploited. Herein, we hypothesize that nanostructured lipid carriers (NLCs) could activate the endogenous glucagon-like peptide-1 (GLP-1) secretion and also act as oral delivery systems for GLP-1 analogs (exenatide and liraglutide). NLCs effectively encapsulated the peptides, the majority of which were only released under the intestinal conditions. NLCs, with and without peptide encapsulation, showed effective induction of GLP-1 secretion in vitro from the enteroendocrinal L-cells (GLUTag). NLCs also showed a 2.9-fold increase in the permeability of exenatide across the intestinal cell monolayer. The intestinal administration of the exenatide and liraglutide loaded NLCs did not demonstrate any glucose lowering effect on normal mice. Further, ex vivo studies depicted that the NLCs mainly adhered to the mucus layer. In conclusion, this study demonstrates that NLCs need further optimization to overcome the mucosal barrier in the intestine; nonetheless, this study also presents a promising strategy to use a dual-action drug delivery nanosystem which synergizes its own biological effect and that of the encapsulated drug molecule. | |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
650 | 7 | a NATURVETENSKAPx Fysik0 (SwePub)1032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Physical Sciences0 (SwePub)1032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Biomaterialvetenskap0 (SwePub)304032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Biomaterials Science0 (SwePub)304032 hsv//eng |
700 | 1 | a Bouttefeux, Orianeu Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium4 aut |
700 | 1 | a Vanvarenberg, Kevinu Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium4 aut |
700 | 1 | a Lundquist, Patriku Uppsala universitet,Institutionen för farmaci,Uppsala University, Sweden4 aut0 (Swepub:uu)patlu774 |
700 | 1 | a Cunarro, Juanu Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain4 aut |
700 | 1 | a Tovar, Sulayu Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain4 aut |
700 | 1 | a Khodus, Georgiyu Uppsala universitet,Institutionen för farmaci,Uppsala University, Sweden4 aut |
700 | 1 | a Andersson, Ellenu Vrinnevi Hosp, Dept Surg, Norrkoping, Sweden.,Vrinnevi Hospital, Sweden4 aut |
700 | 1 | a Keita, Åsau Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US4 aut0 (Swepub:liu)asave24 |
700 | 1 | a Dieguez, Carlos Gonzalezu Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain4 aut |
700 | 1 | a Artursson, Peru Uppsala universitet,Institutionen för farmaci,Uppsala University, Sweden4 aut0 (Swepub:uu)perartur |
700 | 1 | a Preat, Veroniqueu Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium4 aut |
700 | 1 | a Beloqui, Anau Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium4 aut |
710 | 2 | a Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.b Catholic University of Louvain, Belgium4 org |
773 | 0 | t Nanoscaled : Royal Society of Chemistry (RSC)g 10:2, s. 603-613q 10:2<603-613x 2040-3364x 2040-3372 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341488 |
856 | 4 8 | u https://doi.org/10.1039/c7nr07736j |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-144245 |
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