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The stimulation of ...
The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers
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- Shrestha, Neha (författare)
- Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium
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- Bouttefeux, Oriane (författare)
- Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium
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- Vanvarenberg, Kevin (författare)
- Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium
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- Lundquist, Patrik (författare)
- Uppsala universitet,Institutionen för farmaci,Uppsala University, Sweden
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- Cunarro, Juan (författare)
- Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain
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- Tovar, Sulay (författare)
- Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain
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- Khodus, Georgiy (författare)
- Uppsala universitet,Institutionen för farmaci,Uppsala University, Sweden
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- Andersson, Ellen (författare)
- Vrinnevi Hosp, Dept Surg, Norrkoping, Sweden.,Vrinnevi Hospital, Sweden
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- Keita, Åsa (författare)
- Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Dieguez, Carlos Gonzalez (författare)
- Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis, Biomed Res Grp, Santiago De Compostela 15782, Spain.,University of Santiago de Compostela, Spain
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- Artursson, Per (författare)
- Uppsala universitet,Institutionen för farmaci,Uppsala University, Sweden
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- Preat, Veronique (författare)
- Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium
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- Beloqui, Ana (författare)
- Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium.,Catholic University of Louvain, Belgium
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Catholic Univ Louvain, Louvain Drug Res Inst, Adv Drug Delivery & Biomat, B-1200 Brussels, Belgium Catholic University of Louvain, Belgium (creator_code:org_t)
- 2018
- 2018
- Engelska.
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Ingår i: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3364 .- 2040-3372. ; 10:2, s. 603-613
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Nanoparticulate based drug delivery systems have been extensively studied to efficiently encapsulate and deliver peptides orally. However, most of the existing data mainly focus on the nanoparticles as a drug carrier, but the ability of nanoparticles having a biological effect has not been exploited. Herein, we hypothesize that nanostructured lipid carriers (NLCs) could activate the endogenous glucagon-like peptide-1 (GLP-1) secretion and also act as oral delivery systems for GLP-1 analogs (exenatide and liraglutide). NLCs effectively encapsulated the peptides, the majority of which were only released under the intestinal conditions. NLCs, with and without peptide encapsulation, showed effective induction of GLP-1 secretion in vitro from the enteroendocrinal L-cells (GLUTag). NLCs also showed a 2.9-fold increase in the permeability of exenatide across the intestinal cell monolayer. The intestinal administration of the exenatide and liraglutide loaded NLCs did not demonstrate any glucose lowering effect on normal mice. Further, ex vivo studies depicted that the NLCs mainly adhered to the mucus layer. In conclusion, this study demonstrates that NLCs need further optimization to overcome the mucosal barrier in the intestine; nonetheless, this study also presents a promising strategy to use a dual-action drug delivery nanosystem which synergizes its own biological effect and that of the encapsulated drug molecule.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Shrestha, Neha
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Bouttefeux, Oria ...
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Vanvarenberg, Ke ...
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Lundquist, Patri ...
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Cunarro, Juan
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Tovar, Sulay
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visa fler...
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Khodus, Georgiy
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Andersson, Ellen
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Keita, Åsa
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Dieguez, Carlos ...
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Artursson, Per
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Preat, Veronique
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Beloqui, Ana
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Fysik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Biomaterialveten ...
- Artiklar i publikationen
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Nanoscale
- Av lärosätet
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Uppsala universitet
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Linköpings universitet