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Overall and periphe...
Overall and peripheral lung function assessment by spirometry and forced oscillation technique in relation to asthma diagnosis and control.
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- Heijkenskjöld Rentzhog, Charlotte (författare)
- Uppsala universitet,Pediatrisk inflammationsforskning
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Berglund, L (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Borres, Magnus P, 1956- (författare)
- Uppsala universitet,Pediatrisk inflammationsforskning
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- Nordvall, Lennart (författare)
- Uppsala universitet,Pediatrisk inflammationsforskning
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- Alving, Kjell, 1959- (författare)
- Uppsala universitet,Pediatrisk inflammationsforskning
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- Malinovschi, Andrei, 1978- (författare)
- Uppsala universitet,Klinisk fysiologi
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(creator_code:org_t)
- 2017-10-20
- 2017
- Engelska.
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Ingår i: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 47:12, s. 1546-1554
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Classic spirometry is effort dependent and of limited value in assessing small airways. Peripheral airway involvement, and relation to poor control, in asthma, has been highlighted recently. Forced oscillation technique (FOT) offers an effort-independent assessment of overall and peripheral lung mechanics. We studied the association between lung function variables, obtained either by spirometry or multifrequency (5, 11 and 19 Hz) FOT, and asthma diagnosis and control.METHODS: ), resistance difference between 5-19 Hz (R5-R19) and Asthma Control Test scores were determined in 234 asthmatic and 60 healthy subjects (aged 13-39 years). We used standardized lung function variables in logistic regression analyses, unadjusted and adjusted for age, height, gender and weight.RESULTS: and R5-R19) were associated with uncontrolled asthma (P-values < .05).CONCLUSIONS: /FVC, supporting a complementary role for FOT. Asthma control was related to FOT measures of peripheral airways, suggesting a potential use in identifying such involvement. Further studies are needed to determine a clinical value and relevant reference values in children, for the multifrequency FOT measurements.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- asthma
- asthma control
- forced oscillation technique
- lung function
- small airways
- spirometry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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