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Elevated inflammati...
Elevated inflammation in association with alcohol abuse among Blacks but not Whites : results from the MIDUS biomarker study
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- Ransome, Yusuf (författare)
- Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, USA
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- Slopen, Natalie (författare)
- Department of Epidemiology and Biostatistics, University of Maryland School of Public Health, USA
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- Karlsson, Oskar (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Center for Molecular Medicine, Karolinska Institute, Solna, Sweden
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- Williams, David R (författare)
- Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, USA
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(creator_code:org_t)
- 2017-12-11
- 2018
- Engelska.
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Ingår i: Journal of behavioral medicine. - : Springer Science and Business Media LLC. - 0160-7715 .- 1573-3521. ; 41:3, s. 374-384
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Some studies document racial disparities in self-reported health associated with alcohol use and abuse. However, few studies examined biomarkers that underlie the onset of alcohol-related chronic diseases. We investigated whether the association between alcohol abuse and five biomarkers of inflammation (CRP, IL-6, fibrinogen, E-selectin, sICAM-1) vary between Black and White Americans aged 35 to 84 (n = 1173) from the Midlife in the United States Biomarker Study. Multivariable Ordinary Least Squares regressions were used to assess Black-White differences in the association between alcohol abuse and the biomarkers. Race moderated the association between alcohol abuse and CRP (b = 0.56, SE = 0.28, p = 0.048), IL-6 (b = 0.65, SE = 0.22, p = 0.004), and a composite inflammation score (b = 0.014, SE = 0.07, p = 0.041). These findings potentially shed light for why alcohol has a stronger negative association with poorer health for Blacks compared to Whites. Analysis should be replicated in larger prospective cohorts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Alcohol abuse
- Biological markers
- Chronic disease
- Inflammation
- MIDUS
- Race/ethnicity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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