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RNA-based regulatio...
RNA-based regulation in type I toxin-antitoxin systems and its implication for bacterial persistence
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- Berghoff, Bork A. (författare)
- Justus Liebig Univ, Inst Mikrobiol & Mol Biol, D-35392 Giessen, Germany.
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- Wagner, Gerhart E. H. (författare)
- Uppsala universitet,Institutionen för cell- och molekylärbiologi
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Justus Liebig Univ, Inst Mikrobiol & Mol Biol, D-35392 Giessen, Germany Institutionen för cell- och molekylärbiologi (creator_code:org_t)
- 2017-05-30
- 2017
- Engelska.
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Ingår i: Current Genetics. - : Springer Science and Business Media LLC. - 0172-8083 .- 1432-0983. ; 63:6, s. 1011-1016
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Abstract
Ämnesord
Stäng
- Bacterial dormancy is a valuable survival strategy upon challenging environmental conditions. Dormant cells tolerate the consequences of high stress levels and may re-populate the environment upon return to favorable conditions. Antibiotic-tolerant bacteria-termed persisters-regularly cause relapsing infections, increase the likelihood of antibiotic resistance, and, therefore, earn increasing attention. Their generation often depends on toxins from chromosomal toxin-antitoxin systems. Here, we review recent insights concerning RNA-based control of toxin synthesis, and discuss possible implications for persister generation.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Toxin-antitoxin
- Antisense RNA
- 5 ' UTR structure
- Persistence
- Depolarization
- SOS response
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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