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Heterogeneity in re...
Heterogeneity in retinoblastoma : a tale of molecules and models
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- Stenfelt, Sonya (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi
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- Blixt, Maria K. E. (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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- All-Ericsson, Charlotta (författare)
- S T Eriks Ogonsjukhus, Karolinska Inst, Stockholm, Sweden.
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- Hallböök, Finn, 1962- (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi
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- Boije, Henrik (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi
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(creator_code:org_t)
- 2017-11-09
- 2017
- Engelska.
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Ingår i: CLINICAL AND TRANSLATIONAL MEDICINE. - : BIOMED CENTRAL LTD. - 2001-1326. ; 6
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that can affect RB1 resulting in different clinical outcomes. In addition, other transformations, such as MYCN amplification, generate particularly aggressive tumors, which may or may not be RB1 independent. Recognizing the cellular characteristics required for tumor development, by identifying the elusive cell-of-origin for retinoblastoma, would help us understand the development of these tumors. In this review we summarize the heterogeneity reported in retinoblastoma on a molecular, cellular and tissue level. We also discuss the challenging heterogeneity in current retinoblastoma models and suggest future platforms that could contribute to improved understanding of tumor initiation, progression and metastasis in retinoblastoma, which may ultimately lead to more patient-specific treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Cancer
- Cell-of-origin
- Genetics
- Horizontal cells
- MYCN
- Photoreceptors
- OTX2
- RB1
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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