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Paternal easiRNAs r...
Paternal easiRNAs regulate parental genome dosage in Arabidopsis
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- Martinez-Arias, Germán (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Swedish Univ Agr Sci, Dept Plant Biol, Uppsala, Sweden.;Linnean Ctr Plant Biol, Uppsala, Sweden.
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- Wolff, Philip (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Swedish Univ Agr Sci, Dept Plant Biol, Uppsala, Sweden.;Linnean Ctr Plant Biol, Uppsala, Sweden.;John Innes Ctr, Norwich, Norfolk, England.
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- Wang, Zhenxing (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Swedish Univ Agr Sci, Dept Plant Biol, Uppsala, Sweden.;Linnean Ctr Plant Biol, Uppsala, Sweden.
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- Moreno Romero, Jordi (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Swedish Univ Agr Sci, Dept Plant Biol, Uppsala, Sweden.;Linnean Ctr Plant Biol, Uppsala, Sweden.;CSIC IRTA UAB UB, CRAG, Barcelona, Spain.
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- Santos-González, Juan (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Swedish Univ Agr Sci, Dept Plant Biol, Uppsala, Sweden.;Linnean Ctr Plant Biol, Uppsala, Sweden.
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- Conze, Lei Liu (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Vaskulärbiologi,Swedish Univ Agr Sci, Dept Plant Biol, Uppsala, Sweden.;Linnean Ctr Plant Biol, Uppsala, Sweden,Institutionen för växtbiologi,Department of Plant Biology
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- DeFraia, Christopher (författare)
- Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA.;Ohio State Univ, Ctr RNA Biol, Columbus, OH 43210 USA.;Ferris State Univ, Dept Biol Sci, Big Rapids, MI USA.
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- Slotkin, R. Keith (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Köhler, Claudia (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för växtbiologi,Department of Plant Biology,Swedish Univ Agr Sci, Dept Plant Biol, Uppsala, Sweden.;Linnean Ctr Plant Biol, Uppsala, Sweden.
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(creator_code:org_t)
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- 2018-01-15
- 2018
- Engelska.
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Ingår i: Nature Genetics. - : NATURE PUBLISHING GROUP. - 1061-4036 .- 1546-1718. ; 50:2, s. 193-198
- Relaterad länk:
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https://www.biorxiv....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- The regulation of parental genome dosage is of fundamental importance in animals and plants, as exemplified by X-chromosome inactivation and dosage compensation. The 'triploid block' is a classic example of dosage regulation in plants that establishes a reproductive barrier between species differing in chromosome number(1,2). This barrier acts in the embryo-nourishing endosperm tissue and induces the abortion of hybrid seeds through a yet unknown mechanism(3). Here we show that depletion of paternal epigenetically activated small interfering RNAs (easiRNAs) bypasses the triploid block in response to increased paternal ploidy in Arabidopsis thaliana. Paternal loss of the plant-specific RNA polymerase IV suppressed easiRNA formation and rescued triploid seeds by restoring small-RNA-directed DNA methylation at transposable elements (TEs), correlating with reduced expression of paternally expressed imprinted genes (PEGs). Our data suggest that easiRNAs form a quantitative signal for paternal chromosome number and that their balanced dosage is required for post-fertilization genome stability and seed viability.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
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- art (ämneskategori)
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