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Assessment of Impac...
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Hill, Brian T.Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH, USA
(författare)
Assessment of Impact of HLA Type on Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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Elsevier BV,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-351084
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-351084URI
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https://doi.org/10.1016/j.bbmt.2017.10.015DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137861697URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy with many highly effective therapies. Chemorefractory disease, often characterized by deletion of chromosome 17p, has historically been associated with very poor outcomes, leading to the application of allogeneic hematopoietic stem cell transplantation (allo-HCT) for medically fit patients. Although the use of allo-HCT has declined since the introduction of novel targeted therapy for the treatment of CLL, there remains significant interest in understanding factors that may influence the efficacy of allo-HCT, the only known curative treatment for CLL. The potential benefit of transplantation is most likely due to the presence of alloreactive donor T cells that mediate the graft-versus-leukemia (GVL) effect. The recognition of potentially tumor-specific antigens in the context of class I and II major histocompatibility complex on malignant B lymphocytes by donor T cells may be influenced by subtle differences in the highly polymorphic HLA locus. Given previous reports of specific HLA alleles impacting the incidence of CLL and the clinical outcomes of allo-HCT for CLL, we sought to study the overall survival and progression-free survival of a large cohort of patients with CLL who underwent allo-HCT from fully HLA-matched related and unrelated donors at Center for International Blood and Marrow Transplant Research transplantation centers. We found no statistically significant association of allo-HCT outcomes in CLL based on previously reported HLA combinations. Additional study is needed to further define the immunologic features that portend a more favorable GVL effect after allo-HCT for CLL.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ahn, Kwang WooMed Coll Wisconsin, Ctr Int Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI, USA
(författare)
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Hu, Zhen-HuanMed Coll Wisconsin, Ctr Int Blood & Marrow Transplantat, Milwaukee, WI, USA; Med Coll Wisconsin, Dept Med, Milwaukee, WI, USA
(författare)
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Aljurf, MahmoudKing Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia
(författare)
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Beitinjaneh, AmerUniv Miami, Miami, FL, USA
(författare)
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Cahn, Jean-YvesUniv Hosp, Dept Hematol, Grenoble, France
(författare)
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Cerny, JanUMass Mem Med Ctr, Worcester, MA USA
(författare)
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Kharfan-Dabaja, Mohamed A.H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL, USA
(författare)
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Ganguly, SiddharthaUniv Kansas, Med Ctr, Div Hematol & Oncol, Blood & Marrow Transplantat, Kansas City, KS, USA
(författare)
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Ghosh, NilanjanCarolinas Healthcare Syst, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC, USA
(författare)
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Grunwald, Michael R.Carolinas Healthcare Syst, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC, USA
(författare)
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Inamoto, YoshihiroNatl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan
(författare)
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Kindwall-Keller, TamilaUniv Virginia Hlth Syst, Div Hematol Oncol, Charlottesville, VA, USA
(författare)
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Nishihori, TaigaH Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL, USA
(författare)
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Olsson, Richard F.Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Div Therapeut Immunol, Dept Lab Med, Stockholm, Sweden(Swepub:uu)riols677
(författare)
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Saad, AymanUniv Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL, USA
(författare)
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Seftel, MatthewCancerCare Manitoba, Dept Med Oncol & Hematol, Winnipeg, MB, Canada
(författare)
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Seo, SachikoNatl Canc Res Ctr East, Dept Hematol & Oncol, Chiba, Japan
(författare)
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Szer, JeffreyRoyal Melbourne Hosp, Dept Clin Haematol & Bone Marrow Transplantat, Parkville, Vic, Australia
(författare)
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Tallman, MartinMem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, New York, USA
(författare)
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Ustun, CelalettinUniv Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN, USA
(författare)
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Wiernik, Peter H.Our Lady Mercy Med Ctr, Bronx, NY USA
(författare)
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Maziarz, Richard T.Oregon Hlth & Sci Univ, Knight Canc Inst, Adult Blood & Marrow Stem Cell Transplant Program, Portland, OR, USA
(författare)
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Kalaycio, MattCleveland Clin, Cleveland, OH, USA
(författare)
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Alyea, EdwinDana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA, USA
(författare)
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Popat, UdayMD Anderson Canc Ctr, Houston, TX USA
(författare)
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Sobecks, RonaldCleveland Clin, Cleveland, OH, USA
(författare)
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Saber, WaelMed Coll Wisconsin, Ctr Int Blood & Marrow Transplantat, Milwaukee, WI, USA; Med Coll Wisconsin, Dept Med, Milwaukee, WI, USA
(författare)
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Cleveland Clin, Taussig Canc Inst, Dept Hematol & Med Oncol, Cleveland, OH, USAMed Coll Wisconsin, Ctr Int Blood & Marrow Transplantat, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI, USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Biology of blood and marrow transplantation: Elsevier BV24:3, s. 581-5861083-87911523-6536
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Till lärosätets databas
- Av författaren/redakt...
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Hill, Brian T.
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Ahn, Kwang Woo
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Hu, Zhen-Huan
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Aljurf, Mahmoud
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Beitinjaneh, Ame ...
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Cahn, Jean-Yves
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visa fler...
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Cerny, Jan
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Kharfan-Dabaja, ...
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Ganguly, Siddhar ...
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Ghosh, Nilanjan
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Grunwald, Michae ...
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Inamoto, Yoshihi ...
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Kindwall-Keller, ...
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Nishihori, Taiga
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Olsson, Richard ...
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Saad, Ayman
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Seftel, Matthew
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Seo, Sachiko
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Szer, Jeffrey
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Tallman, Martin
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Ustun, Celaletti ...
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Wiernik, Peter H ...
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Maziarz, Richard ...
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Kalaycio, Matt
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Alyea, Edwin
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Popat, Uday
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Sobecks, Ronald
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Saber, Wael
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Biology of blood ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet