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The elusive ligand ...
The elusive ligand complexes of the DWARF14 strigolactone receptor
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- Carlsson, Gunilla H. (författare)
- Uppsala universitet,Molekylär biofysik
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- Hasse, Dirk (författare)
- Uppsala universitet,Molekylär biofysik
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- Cardinale, Francesca (författare)
- Univ Turin, Dept Agr Forestry & Food Sci, Largo Paolo Braccini 2, I-10095 Grugliasco 2, Italy
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- Prandi, Cristina (författare)
- Univ Turin, Dept Chem, Via P Giuria 7, I-10125 Turin, Italy
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- Andersson, Inger (författare)
- Uppsala universitet,Molekylär biofysik
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(creator_code:org_t)
- 2018-01-31
- 2018
- Engelska.
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Ingår i: Journal of Experimental Botany. - : Oxford University Press (OUP). - 0022-0957 .- 1460-2431. ; 69:9, s. 2345-2354
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Strigolactones, a group of terpenoid lactones, control many aspects of plant growth and development, but the active forms of these plant hormones and their mode of action at the molecular level are still unknown. The strigolactone protein receptor is unusual because it has been shown to cleave the hormone and supposedly forms a covalent bond with the cleaved hormone fragment. This interaction is suggested to induce a conformational change in the receptor that primes it for subsequent interaction with partners in the signalling pathway. Substantial efforts have been invested into describing the interaction of synthetic strigolactone analogues with the receptor, resulting in a number of crystal structures. This investigation combines a re-evaluation of models in the Protein Data Bank with a search for new conditions that may permit the capture of a receptor-ligand complex. While weak difference density is frequently observed in the binding cavity, possibly due to a low-occupancy compound, the models often contain features not supported by the X-ray data. Thus, at this stage, we do not believe that any detailed deductions about the nature, conformation, or binding mode of the ligand can be made with any confidence.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Crystal structure
- DWARF14
- ligand binding
- Oryza sativa
- strigolactone
- strigolactone receptor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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