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Evaluation of quant...
Evaluation of quantitative CMR perfusion imaging by comparison with simultaneous 15O-water-PET
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- Kero, Tanja (författare)
- Uppsala universitet,Radiologi,Medical Imaging Centre, Uppsala University Hospital
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- Johansson, Edvin (författare)
- Antaros Medical
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- Engström, Mathias (författare)
- GE Healthcare
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- Eggers, Kai M., 1962- (författare)
- Uppsala universitet,Kardiologi
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- Johansson, Lars (författare)
- Antaros Medical
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- Ahlström, Håkan, 1953- (författare)
- Uppsala universitet,Radiologi,Antaros Medical
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi,Medical Physics, Uppsala University Hospital
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(creator_code:org_t)
- 2019-07-16
- 2021
- Engelska.
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Ingår i: Journal of Nuclear Cardiology. - : Springer Science and Business Media LLC. - 1071-3581 .- 1532-6551. ; 28, s. 1252-1266
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundWe assessed the quantitative accuracy of cardiac perfusion measurements using dynamic contrast-enhanced MRI with simultaneous 15O-water PET as reference with a fully integrated PET-MR scanner.Methods15 patients underwent simultaneous DCE MRI and 15O-water PET scans at rest and adenosine-stress on an integrated PET-MR scanner. Correlation and agreement between MRI- and PET-based global and regional MBF values were assessed using correlation and Bland–Altman analysis.ResultsThree subjects were excluded due to technical problems. Global mean (± SD) MBF values at rest and stress were 0.97 ± 0.27 and 3.19 ± 0.70 mL/g/min for MRI and 1.02 ± 0.28 and 3.13 ± 1.16 mL/g/min for PET (P = 0.66 and P = 0.81). The correlations between global and regional MRI- and PET-based MBF values were strong (r = 0.86 and r = 0.75). The biases were negligible for both global and regional MBF comparisons (0.01 and 0.00 mL/min/g for both), but the limits of agreement were wide for both global and regional MBF, with larger variability for high MBF-values.ConclusionThe correlation between simultaneous MBF measurements with DCE MRI and 15O-water PET measured in an integrated PET-MRI was strong but the agreement was only moderate indicating that MRI-based quantitative MBF measurements is not ready for clinical introduction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- myocardial perfusion
- myocardial blood flow
- cardiac magnetic resonance imaging
- positron emission tomography
- quantitative modeling
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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