Sökning: onr:"swepub:oai:DiVA.org:uu-357270" > Adjusted Troponin I...
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000 | 06474naa a2200541 4500 | |
001 | oai:DiVA.org:uu-357270 | |
003 | SwePub | |
008 | 180817s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3572702 URI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Boeckel, Jes-Nielsu Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany;Univ Hosp Leipzig, Dept Internal Med, Cardiol, Leipzig, Germany4 aut |
245 | 1 0 | a Adjusted Troponin I for Improved Evaluation of Patients with Chest Pain |
264 | 1 | b NATURE PUBLISHING GROUP,c 2018 |
338 | a electronic2 rdacarrier | |
520 | a The use of cardiac troponins (cTn) is the gold standard for diagnosing myocardial infarction. Independent of myocardial infarction (MI), however, sex, age and kidney function affect cTn levels. Here we developed a method to adjust cTnI levels for age, sex, and renal function, maintaining a unified cut-off value such as the 99th percentile. A total of 4587 individuals enrolled in a prospective longitudinal study were used to develop a model for adjustment of cTn. cTnI levels correlated with age and estimated glomerular filtration rate (eGFR) in males/females with r(age) = 0.436/0.518 and with (r)(eGFR) = -0.142/-0.207. For adjustment, these variables served as covariates in a linear regression model with cTnl as dependent variable. This adjustment model was then applied to a real-world cohort of 1789 patients with suspected acute MI (AMI) (N = 407). Adjusting cTnI showed no relevant loss of diagnostic information, as evidenced by comparable areas under the receiver operator characteristic curves, to identify AMI in males and females for adjusted and unadjusted cTnI. In specific patients groups such as in elderly females, adjusting cTnI improved specificity for AMI compared with unadjusted cTnI. Specificity was also improved in patients with renal dysfunction by using the adjusted cTnI values. Thus, the adjustments improved the diagnostic ability of cTnI to identify AMI in elderly patients and in patients with renal dysfunction. Interpretation of cTnI values in complex emergency cases is facilitated by our method, which maintains a single diagnostic cut-off value in all patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Palapies, Larsu Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany4 aut |
700 | 1 | a Klotsche, Jensu Tech Univ Dresden, Clin Psychol & Psychotherapy, Dresden, Germany4 aut |
700 | 1 | a Zeller, Tanjau German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany4 aut |
700 | 1 | a von Jeinsen, Beatriceu Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany4 aut |
700 | 1 | a Perret, Maya F.u Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany4 aut |
700 | 1 | a Kleinhaus, Soeren L.u Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany4 aut |
700 | 1 | a Pieper, Larsu Tech Univ Dresden, Clin Psychol & Psychotherapy, Dresden, Germany4 aut |
700 | 1 | a Tzikas, Stergiosu Aristotle Univ Thessaloniki, Ippokrateio Hosp, Dept Cardiol 3, Thessaloniki, Greece;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 2, Mainz, Germany4 aut |
700 | 1 | a Leistner, Davidu Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany4 aut |
700 | 1 | a Bickel, Christophu Fed Armed Forces Hosp, Dept Internal Med, Koblenz, Germany4 aut |
700 | 1 | a Stalla, Guenter K.u Max Planck Inst Psychiat, Neuroendocrinol, Munich, Germany4 aut |
700 | 1 | a Lehnert, Hendriku Univ Hosp Schleswig Holstein, Dept Internal Med 1, Lubeck, Germany4 aut |
700 | 1 | a Lindahl, Bertil,d 1957-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)belin227 |
700 | 1 | a Wittchen, Hans-Ulrichu Tech Univ Dresden, Clin Psychol & Psychotherapy, Dresden, Germany4 aut |
700 | 1 | a Silber, Sigmundu Praxisklin, Kardiol Gemeinschaftspraxis, Munich, Germany4 aut |
700 | 1 | a Baldus, Stephanu Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany;Univ Cologne, Heart Ctr, Cologne, Germany4 aut |
700 | 1 | a Maerz, Winfriedu Synlab Serv GmbH, Synlab Akad Arztl Fortbildung, Mannheim, Germany4 aut |
700 | 1 | a Dimmeler, Stefanieu German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany4 aut |
700 | 1 | a Blankenberg, Stefanu German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany4 aut |
700 | 1 | a Muenzel, Thomasu German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 2, Mainz, Germany4 aut |
700 | 1 | a Zeiher, Andreas M.u Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany4 aut |
700 | 1 | a Keller, Tillu Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Kerckhoff Heart & Thorax Ctr, Bad Nauheim, Germany4 aut |
710 | 2 | a Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany;German Ctr Cardiovasc Dis DZHK, Berlin, Germany;Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany;Univ Hosp Leipzig, Dept Internal Med, Cardiol, Leipzig, Germanyb Goethe Univ Frankfurt, Univ Hosp, Dept Internal Med 3, Cardiol, Frankfurt, Germany4 org |
773 | 0 | t Scientific Reportsd : NATURE PUBLISHING GROUPg 8q 8x 2045-2322 |
856 | 4 | u https://doi.org/10.1038/s41598-018-26120-ly Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1239735/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-357270 |
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