Sökning: onr:"swepub:oai:DiVA.org:uu-357383" > T cells are influen...
Fältnamn | Indikatorer | Metadata |
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000 | 04241naa a2200577 4500 | |
001 | oai:DiVA.org:uu-357383 | |
003 | SwePub | |
008 | 180824s2018 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:138396170 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3573832 URI |
024 | 7 | a https://doi.org/10.1016/j.jaut.2018.01.0032 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1383961702 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Houtman, Mirandau Karolinska Institutet4 aut |
245 | 1 0 | a T cells are influenced by a long non-coding RNA in the autoimmune associated PTPN2 locus |
264 | 1 | b ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD,c 2018 |
338 | a electronic2 rdacarrier | |
520 | a Non-coding SNPs in the protein tyrosine phosphatase non-receptor type 2 (PTPN2) locus have been linked with several autoimmune diseases, including rheumatoid arthritis, type I diabetes, and inflammatory bowel disease. However, the functional consequences of these SNPs are poorly characterized. Herein, we show in blood cells that SNPs in the PTPN2 locus are highly correlated with DNA methylation levels at four CpG sites downstream of PTPN2 and expression levels of the long non-coding RNA (IncRNA) LINC01882 downstream of these CpG sites. We observed that LINC01882 is mainly expressed in T cells and that anti-CD3/CD28 activated naive CD4(+) T cells downregulate the expression of LINC01882. RNA sequencing analysis of LINC01882 knockdown in Jurkat T cells, using a combination of antisense oligo-nucleotides and RNA interference, revealed the upregulation of the transcription factor ZEB1 and kinase MAP2K4, both involved in IL-2 regulation. Overall, our data suggests the involvement of LINC01882 in T cell activation and hints towards an auxiliary role of these non-coding SNPs in autoimmunity associated with the PTPN2 locus. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a RA | |
653 | a Genome-wide association | |
653 | a methQTL | |
653 | a eQTL | |
653 | a Long non-coding RNA | |
653 | a T cell | |
700 | 1 | a Shchetynsky, Klementyu Karolinska Institutet4 aut |
700 | 1 | a Chemin, Karineu Karolinska Institutet4 aut |
700 | 1 | a Hensvold, Aase Haju Karolinska Institutet4 aut |
700 | 1 | a Ramsköld, Danielu Karolinska Institutet4 aut |
700 | 1 | a Tandre, Karolinau Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)karotand |
700 | 1 | a Eloranta, Maija-Leenau Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)maelo020 |
700 | 1 | a Rönnblom, Larsu Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)larsronn |
700 | 1 | a Uebe, Steffenu Univ Erlangen Nurnberg, Inst Human Genet, Erlangen, Germany4 aut |
700 | 1 | a Catrina, Anca Irinelu Karolinska Institutet4 aut |
700 | 1 | a Malmström, Vivianneu Karolinska Institutet4 aut |
700 | 1 | a Padyukov, Leonidu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Reumatologi4 org |
773 | 0 | t Journal of Autoimmunityd : ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDg 90, s. 28-38q 90<28-38x 0896-8411x 1095-9157 |
856 | 4 | u https://doi.org/10.1016/j.jaut.2018.01.003y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1241617/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1016/j.jaut.2018.01.003 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-357383 |
856 | 4 8 | u https://doi.org/10.1016/j.jaut.2018.01.003 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138396170 |
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