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Neurosurgical patte...
Neurosurgical patterns of care for diffuse low-grade gliomas in Sweden between 2005 and 2015
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- Carstam, Louise (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Smits, Anja (författare)
- Gothenburg University,Göteborgs universitet,Uppsala universitet,Neurologi,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden,Univ Gothenburg, Sweden; Uppsala Univ, Sweden,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation
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- Milos, Peter, 1969- (författare)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurokirurgiska kliniken US,Linköping Univ Hosp, Dept Neurosurg, Linköping, Sweden
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- Corell, Alba (författare)
- Sahlgrens Univ Hosp, Dept Neurosurg, Gothenburg, Sweden
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- Henriksson, Roger (författare)
- Umeå universitet,Onkologi,Reg Canc Ctr Stockholm Gotland, Stockholm, Sweden; Univ Umeå, Dept Radiat Sci & Oncol, Umeå, Sweden
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- Bartek, Jiri Jr (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Neurosurg, Stockholm, Sweden; Karolinska Inst, Dept Neurosci, Stockholm, Sweden; Karolinska Inst, Dept Med, Stockholm, Sweden; Copenhagen Univ Hosp, Rigshosp, Dept Neurosurg, Copenhagen, Denmark
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- Jakola, Asgeir Store (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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(creator_code:org_t)
- 2018-07-17
- 2018
- Engelska.
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Ingår i: Neuro-Oncology Practice. - : Oxford University Press. - 2054-2577 .- 2054-2585. ; 6:2, s. 124-133
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Abstract
Ämnesord
Stäng
- Background: In the last decade, increasing evidence has evolved for early and maximal safe resection of diffuse low-grade gliomas (LGGs) regarding survival. However, changes in clinical practice are known to occur slowly and we do not know if the scientific evidence has yet resulted in changes in neurosurgical patterns of care.Methods: The Swedish Brain Tumor Registry was used to identify all patients with a first-time histopathological diagnosis of LGG between 2005 and 2015. For analysis of surgical treatment patterns, we subdivided assessed time periods into 2005-2008, 2009-2012, and 2013-2015. Population-based data on patient and disease characteristics, surgical management, and outcomes were extracted.Results: A total of 548 patients with diffuse World Health Organization grade II gliomas were identified: 142 diagnosed during 2005-2008, 244 during 2009-2012, and 162 during 2013-2015. Resection as opposed to biopsy was performed in 64.3% during 2005-2008, 74.2% during 2009-2012, and 74.1% during 2013-2015 (P = .08). There was no difference among the 3 periods regarding overall survival (P = .11). However, post hoc analysis of data from the 4 (out of 6) centers that covered all 3 time periods demonstrated a resection rate of 64.3% during 2005-2008, 77.4% during 2009-2012, and 75.4% during 2013-2015 (P = .02) and longer survival of patients diagnosed 2009 and onward (P = .04).Conclusion: In this nationwide, population-based study we observed a shift over time in favor of LGG resection. Further, a positive correlation between the more active surgical strategy and longer survival is shown, although no causality can be claimed because of possible confounding factors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- diffuse low-grade glioma
- glioma/surgery
- neurosurgery
- patterns of care
- treatment outcome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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