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Titanium surface mo...
Titanium surface modification to enhance antibacterial and bioactive properties while retaining biocompatibility
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- Janson, Oscar (författare)
- Uppsala universitet,Tillämpad materialvetenskap,Materials in medicine
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- Gururaj, Satwik (författare)
- Uppsala universitet,Tillämpad materialvetenskap
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- Pujari-Palmer, Shiuli (författare)
- Uppsala universitet,Tillämpad materialvetenskap
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- Karlsson Ott, Marjam, 1975- (författare)
- Uppsala universitet,Tillämpad materialvetenskap
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- Strømme, Maria, 1970- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Engqvist, Håkan, 1972- (författare)
- Uppsala universitet,Tillämpad materialvetenskap
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- Welch, Ken, 1968- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: Materials science & engineering. C, biomimetic materials, sensors and systems. - : Elsevier BV. - 0928-4931 .- 1873-0191. ; 96, s. 272-279
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Bacterial infections associated with metal implants are severe problems affecting a considerable amount of people with dental or orthopedic implants. This study aims to examine the antibacterial effect of a Titanium-peroxy gel layer on the modified surface of commercially pure titanium grade 2. Variations in a multi-step surface modification procedure were tested to determine the best combination that provided an antibacterial effect while enhancing bioactivity without compromising biocompatibility. Soaking the surfaces in 30 wt% hydrogen peroxide held at 80 °C provided antibacterial activity while subsequent surface treatments in concentrated sodium and calcium hydroxide solutions were preformed to enhance bioactivity. Staphylococcus epidermidis was used to determine the antibacterial effect through both direct contact and biofilm inhibition tests while human dermal fibroblast cells and MC3T3 pre osteoblast cells were utilized to test biocompatibility. The greatest antibacterial effect was observed with only hydrogen peroxide treatment, but the resulting surface was neither bioactive nor biocompatible. It was found that subsequent surface treatments with sodium hydroxide followed by calcium hydroxide provided a bioactive surface that was also biocompatible. Additionally, a final treatment with autoclaving showed positive effects with regards to enhanced bioactivity. This multi-step surface modification procedure offers a promising, non-antibiotic, solution for combatting infections associated with biomedical implants.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering (hsv//eng)
Nyckelord
- Titanium
- Antibacterial
- Bioactivity
- Cell viability
- Sodium titanate
- Calcium titanate
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Janson, Oscar
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Gururaj, Satwik
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Pujari-Palmer, S ...
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Karlsson Ott, Ma ...
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Strømme, Maria, ...
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Engqvist, Håkan, ...
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visa fler...
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Welch, Ken, 1968 ...
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visa färre...
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TEKNIK OCH TEKNO ...
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Uppsala universitet