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Characterization of...
Characterization of Nanoparticle Batch-To-Batch Variability
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- Muelhopt, Sonja (författare)
- Karlsruhe Inst Technol, Inst Tech Chem, D-76131 Karlsruhe, Germany
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- Diabate, Silvia (författare)
- Karlsruhe Inst Technol, Inst Toxicol & Genet, D-76131 Karlsruhe, Germany
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- Dilger, Marco (författare)
- Karlsruhe Inst Technol, Inst Toxicol & Genet, D-76131 Karlsruhe, Germany
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- Adelhelm, Christel (författare)
- Karlsruhe Inst Technol, Inst Appl Mat, D-76131 Karlsruhe, Germany
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- Anderlohr, Christopher (författare)
- Karlsruhe Inst Technol, Inst Tech Thermodynam & Refrigerat ITTK, D-76131 Karlsruhe, Germany
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- Bergfeldt, Thomas (författare)
- Karlsruhe Inst Technol, Inst Appl Mat, D-76131 Karlsruhe, Germany
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- Gómez de la Torre, Johan, 1981- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Jiang, Yunhong (författare)
- Univ Bath, Dept Architecture & Civil Engn, Claverton Down, Bath BA2 7AY, Avon, England
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- Valsami-Jones, Eugenia (författare)
- Univ Birmingham, Sch Geog Earth & Environm Sci, Birmingham B15 2TT, W Midlands, England
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- Langevin, Dominique (författare)
- Univ Paris Saclay, Univ Paris Sud 11, CNRS UMR 8502, Lab Phys Solides, F-91190 St Aubin, France
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- Lynch, Iseult (författare)
- Univ Birmingham, Sch Geog Earth & Environm Sci, Birmingham B15 2TT, W Midlands, England
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- Mahon, Eugene (författare)
- Univ Coll Dublin, Sch Chem & Chem Biol, Ctr BioNano Interact, Dublin 4, Ireland
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- Nelissen, Inge (författare)
- Flemish Inst Technol Res VITO, Dept Hlth, B-2400 Mol, Belgium
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- Piella, Jordi (författare)
- CSIC, Catalan Inst Nanosci & Nanotechnol ICN2, Barcelona 08036, Spain;Barcelona Inst Sci & Technol, Barcelona 08036, Spain
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- Puntes, Victor (författare)
- CSIC, Catalan Inst Nanosci & Nanotechnol ICN2, Barcelona 08036, Spain;Barcelona Inst Sci & Technol, Barcelona 08036, Spain
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- Ray, Sikha (författare)
- Karlsruhe Inst Technol, STN, D-76131 Karlsruhe, Germany
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- Schneider, Reinhard (författare)
- Karlsruhe Inst Technol, LEM, D-76131 Karlsruhe, Germany
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- Wilkins, Terry (författare)
- Univ Leeds, Sch Chem & Proc Engn, Fac Engn, Leeds LS2 9JT, W Yorkshire, England
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- Weiss, Carsten (författare)
- Karlsruhe Inst Technol, Inst Toxicol & Genet, D-76131 Karlsruhe, Germany
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- Paur, Hanns-Rudolf (författare)
- Karlsruhe Inst Technol, Inst Tech Chem, D-76131 Karlsruhe, Germany
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(creator_code:org_t)
- 2018-05-08
- 2018
- Engelska.
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Ingår i: Nanomaterials. - : MDPI. - 2079-4991. ; 8:5
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicochemical descriptors as prioritized by the OECD have been fully characterized. The study represents the most complete assessment of NMs batch-to-batch variability performed to date and provides numerous important insights into the potential sources of variability of NMs and how these might be reduced.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- nanosafety
- particle size
- impurities
- reactive oxygen species
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Muelhopt, Sonja
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Diabate, Silvia
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Dilger, Marco
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Adelhelm, Christ ...
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Anderlohr, Chris ...
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Bergfeldt, Thoma ...
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visa fler...
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Gómez de la Torr ...
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Jiang, Yunhong
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Valsami-Jones, E ...
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Langevin, Domini ...
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Lynch, Iseult
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Mahon, Eugene
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Nelissen, Inge
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Piella, Jordi
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Puntes, Victor
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Ray, Sikha
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Schneider, Reinh ...
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Wilkins, Terry
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Weiss, Carsten
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Paur, Hanns-Rudo ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Farmakologi och ...
- Artiklar i publikationen
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Nanomaterials
- Av lärosätet
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Uppsala universitet