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Maternal age at del...
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Real, Francisco GomezUniv Bergen, Dept Clin Sci, N-5020 Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynaecol, Bergen, Norway
(författare)
Maternal age at delivery, lung function and asthma in offspring : a population-based survey
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-06-07
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EUROPEAN RESPIRATORY SOC JOURNALS LTD,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-359660
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-359660URI
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https://doi.org/10.1183/13993003.01611-2016DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex. 10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years. In logistic and linear multilevel mixed models we adjusted for participants' characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. Maternal age was validated in a subsample using data from the Norwegian birth registry. Increasing maternal age was associated with increasing forced expiratory volume in 1 s (2.33 mL per year, 95% CI 0.34-4.32 mL per year), more consistent in females (p(trend) 0.025) than in males (ptrend 0.14). Asthma (OR 0.85, 95% CI 0.79-0.92) and respiratory symptoms (OR 0.87, 95% CI 0.82-0.92) decreased with increasing maternal age (per 5 years) in females, but not in males (p(interaction) 0.05 and 0.001, respectively). The results were consistent across centres and not explained by confounding factors. Maternal ageing was related to higher adult lung function and less asthma/symptoms in females. Biological characteristics in offspring related to maternal ageing are plausible and need further investigation.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Burgess, John A.
(författare)
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Villani, SimonaUniv Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia;Univ Pavia, Dept Publ Hlth Expt & Forens Med, Unit Biostat & Clin Epidemiol, Pavia, Italy
(författare)
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Dratva, JuliaSwiss Trop Inst, Inst Social & Prevent Med, Basel, Switzerland
(författare)
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Heinrich, JoachimNatl Res Ctr Environm & Hlth, Mol Epidemiol, Forschungszentrum Umwelt & Gesundheit, Neuherberg, Germany
(författare)
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Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn
(författare)
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Jarvis, DebbieImperial Coll, Dept Publ Hlth Sci, London, England
(författare)
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Koplin, JenniferUniv Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
(författare)
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Leynaert, BenedicteInserm, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France;Univ Paris Diderot Paris 7, Paris, France
(författare)
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Lodge, CarolineUniv Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
(författare)
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Laerum, Birger N.Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway
(författare)
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Matheson, Melanie C.Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
(författare)
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Norbäck, DanUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)dagnorba
(författare)
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Omenaas, Ernst R.Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway;Haukeland Hosp, Ctr Clin Res, Bergen, Norway
(författare)
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Skulstad, Svein M.Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway
(författare)
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Sunyer, JordiCtr Recerca Epidemiol & Ambiental, Barcelona, Spain
(författare)
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Dharmage, Shyamali C.Univ Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
(författare)
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Svanes, CecilieHaukeland Hosp, Dept Occupat Med, Bergen, Norway;Univ Bergen, Ctr Int Hlth, Bergen, Norway
(författare)
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Univ Bergen, Dept Clin Sci, N-5020 Bergen, Norway;Haukeland Hosp, Dept Obstet & Gynaecol, Bergen, NorwayUniv Melbourne, Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia;Univ Pavia, Dept Publ Hlth Expt & Forens Med, Unit Biostat & Clin Epidemiol, Pavia, Italy
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Respiratory Journal: EUROPEAN RESPIRATORY SOC JOURNALS LTD51:60903-19361399-3003
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Till lärosätets databas
- Av författaren/redakt...
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Real, Francisco ...
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Burgess, John A.
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Villani, Simona
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Dratva, Julia
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Heinrich, Joachi ...
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Janson, Christer
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visa fler...
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Jarvis, Debbie
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Koplin, Jennifer
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Leynaert, Benedi ...
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Lodge, Caroline
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Laerum, Birger N ...
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Matheson, Melani ...
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Norbäck, Dan
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Omenaas, Ernst R ...
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Skulstad, Svein ...
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Sunyer, Jordi
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Dharmage, Shyama ...
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Svanes, Cecilie
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