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Phase II Study of t...
Phase II Study of the Efficacy and Safety of Pembrolizumab for Relapsed/Refractory Classic Hodgkin Lymphoma
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- Chen, Robert (författare)
- City Hope Natl Med Ctr, Natl Med Ctr, Duarte, CA USA
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- Zinzani, Pier Luigi (författare)
- Univ Bologna, Bologna, Italy
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- Fanale, Michelle A. (författare)
- Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
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- Armand, Philippe (författare)
- Dana Farber Canc Inst, Boston, MA 02115 USA
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- Johnson, Nathalie A. (författare)
- Jewish Gen Hosp, Montreal, PQ, Canada
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- Brice, Pauline (författare)
- Hop St Louis, Paris, France
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- Radford, John (författare)
- Christie NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England;Univ Manchester, Manchester, Lancs, England
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- Ribrag, Vincent (författare)
- Inst Gustave Roussy, Villejuif, France
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- Molin, Daniel, 1969- (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Vassilakopoulos, Theodoros P. (författare)
- Univ Athens, Laikon Gen Hosp, Athens, Greece
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- Tomita, Akihiro (författare)
- Nagoya Univ, Grad Sch Med, Nagoya, Aichi, Japan
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- von Tresckow, Bastian (författare)
- Univ Hosp Cologne, Cologne, Germany
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- Shipp, Margaret A. (författare)
- Dana Farber Canc Inst, Boston, MA 02115 USA
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- Zhang, Yinghua (författare)
- Merck, Kenilworth, NJ USA
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- Ricart, Alejandro D. (författare)
- Merck, Kenilworth, NJ USA
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- Balakumaran, Arun (författare)
- Merck, Kenilworth, NJ USA
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- Moskowitz, Craig H. (författare)
- Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10065 USA
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 35:19, s. 2125-2132
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Purpose Hodgkin Reed-Sternberg cells harbor alterations in chromosome 9p24.1, leading to overexpression of programmed death-ligand 1 (PD-L1) and PD-L2. Pembrolizumab, a programmed death 1-blocking antibody, demonstrated a high overall response rate (ORR) in patients with relapsed or refractory classic Hodgkin lymphoma (rrHL) in phase I testing. Methods KEYNOTE-087 (ClinicalTrials.gov identifier, NCT02453594) was a single-arm phase II study of pembrolizumab in three cohorts of patients with rrHL, defined on the basis of lymphoma progression after (1) autologous stem cell transplantation (ASCT) and subsequent brentuximab vedotin (BV); (2) salvage chemotherapy and BV, and thus, ineligible for ASCT because of chemoresistant disease; and (3) ASCT, but without BV after transplantation. Patients received pembrolizumab 200 mg once every 3 weeks. Response was assessed every 12 weeks. The primary end points were ORR by central review and safety. Results A total of 210 patients were enrolled and treated (69 in cohort 1, 81 in cohort 2, and 60 in cohort 3). At the time of analysis, patients received a median of 13 treatment cycles. Per central review, the ORR was 69.0% (95% CI, 62.3% to 75.2%), and the complete response rate was 22.4% (95% CI, 16.9% to 28.6%). By cohort, ORRs were 73.9% for cohort 1, 64.2% for cohort 2, and 70.0% for cohort 3. Thirty-one patients had a response >= 6 months. The safety profile was largely consistent with previous pembrolizumab studies. Conclusion Pembrolizumab was associated with high response rates and an acceptable safety profile in patients with rrHL, offering a new treatment paradigm for this disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Chen, Robert
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Zinzani, Pier Lu ...
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Fanale, Michelle ...
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Armand, Philippe
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Johnson, Nathali ...
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Brice, Pauline
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Radford, John
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Ribrag, Vincent
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Molin, Daniel, 1 ...
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Vassilakopoulos, ...
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Tomita, Akihiro
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von Tresckow, Ba ...
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Shipp, Margaret ...
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Zhang, Yinghua
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Ricart, Alejandr ...
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Balakumaran, Aru ...
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Moskowitz, Craig ...
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