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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 13381naa a2201297 4500 | |
| 001 | oai:DiVA.org:uu-362009 | |
| 003 | SwePub | |
| 008 | 181005s2018 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:138766976 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3620092 URI |
| 024 | 7 | a https://doi.org/10.1158/0008-5472.CAN-17-29002 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1387669762 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wang, Sophia S.u City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA;Beckman Res Inst, Dept Populat Sci, Duarte, CA USA4 aut |
| 245 | 1 0 | a HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes |
| 264 | 1 | c 2018 |
| 338 | a print2 rdacarrier | |
| 520 | a A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are associated with increased disease risk. HLA alleles at class I and II loci were imputed from genome-wide association studies (GWAS) using SNP2HLA for 3,617 diffuse large B-cell lymphomas (DLBCL), 2,686 follicular lymphomas (FL), 2,878 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 741 marginal zone lymphomas (MZL), and 8,753 controls of European descent. Both DLBCL and MZL risk were elevated with homozygosity at class I HLA-B and -C loci (OR DLBCL = 1.31, 95% CI = 1.06-1.60; OR MZL = 1.45, 95% CI = 1.12-1.89) and class II HLA-DRB1 locus (OR DLBCL = 2.10, 95% CI = 1.24-3.55; OR MZL = 2.10, 95% CI = 0.99-4.45). Increased FL risk was observed with the overall increase in number of homozygous HLA class II loci (P trend < 0.0001, FDR = 0.0005). These results support a role for HLA zygosity in NHL etiology and suggests that distinct immune pathways may underly the etiology of the different NHL subtypes. Significance: HLA gene diversity reduces risk for non-Hodgkin lymphoma. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Carrington, Maryu Ragon Inst MGH MIT & Harvard, Cambridge, MA USA;Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc & Inflammat Program, Frederick, MD USA4 aut |
| 700 | 1 | a Berndt, Sonja I.u NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA4 aut |
| 700 | 1 | a Slager, Susan L.u Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA4 aut |
| 700 | 1 | a Bracci, Paige M.u Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA4 aut |
| 700 | 1 | a Voutsinas, Jennau City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA;Beckman Res Inst, Dept Populat Sci, Duarte, CA USA4 aut |
| 700 | 1 | a Cerhan, James R.u Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA4 aut |
| 700 | 1 | a Smedby, Karin E.u Karolinska Institutet4 aut |
| 700 | 1 | a Hjalgrim, Henriku Karolinska Institutet4 aut |
| 700 | 1 | a Vijai, Josephu Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA4 aut |
| 700 | 1 | a Morton, Lindsay M.u NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA4 aut |
| 700 | 1 | a Vermeulen, Roelu Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands4 aut |
| 700 | 1 | a Paltiel, Orau Hadassah Hebrew Univ Med Ctr, Braun Sch Publ Hlth & Community Med, Jerusalem, Israel4 aut |
| 700 | 1 | a Vajdic, Claire M.u Univ New South Wales, Ctr Big Data Res Hlth, Sydney, NSW, Australia4 aut |
| 700 | 1 | a Linet, Martha S.u NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA4 aut |
| 700 | 1 | a Nieters, Alexandrau Univ Med Ctr Freiburg, Ctr Chron Immunodeficiency, Freiburg, Baden Wurttembe, Germany4 aut |
| 700 | 1 | a de Sanjose, Silviau CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;IDIBELL, Inst Catala Oncol, Canc Epidemiol Res Programme, Unit Infect & Canc, Barcelona 08908, Spain4 aut |
| 700 | 1 | a Cozen, Wendyu Univ Southern Calif, Dept Pathol, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA;Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA4 aut |
| 700 | 1 | a Brown, Elizabeth E.u Univ Alabama Birmingham, Sch Med, Dept Pathol, Birmingham, AL USA;Univ Alabama Birmingham, UAB Comprehens Canc Ctr, Birmingham, AL USA4 aut |
| 700 | 1 | a Turner, Jenniferu Douglass Hanly Moir Pathol, Dept Histopathol, Sydney, NSW, Australia;Macquarie Univ, Fac Med & Hlth Sci, Sydney, NSW, Australia4 aut |
| 700 | 1 | a Spinelli, John J.u Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada;British Columbia Canc Agcy, Canc Control Res, Vancouver, BC, Canada4 aut |
| 700 | 1 | a Zheng, Tongzhangu Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA4 aut |
| 700 | 1 | a Birmann, Brenda M.u Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA4 aut |
| 700 | 1 | a Flowers, Christopher R.u Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA4 aut |
| 700 | 1 | a Becker, Nikolausu German Canc Res Ctr, Div Clin Epidemiol, Heidelberg, Baden Wurttembe, Germany4 aut |
| 700 | 1 | a Holly, Elizabeth A.u Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA4 aut |
| 700 | 1 | a Kane, Eleanoru Univ York, Dept Hlth Sci, York, N Yorkshire, England4 aut |
| 700 | 1 | a Weisenburger, Dennisu City Hope Natl Med Ctr, Dept Pathol, Duarte, CA USA4 aut |
| 700 | 1 | a Maynadie, Marcu Univ Burgundy, INSERM, UMR1231, Registry Hematol Malignancies Cote Or, Dijon, France;Dijon Univ Hosp, Dijon, France4 aut |
| 700 | 1 | a Cocco, Pierluigiu Univ Cagliari, Dept Publ Hlth Clin & Mol Med, Cagliari, Italy4 aut |
| 700 | 1 | a Albanes, Demetriusu NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA4 aut |
| 700 | 1 | a Weinstein, Stephanie J.u NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA4 aut |
| 700 | 1 | a Teras, Lauren R.u Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA4 aut |
| 700 | 1 | a Diver, W. Ryanu Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA4 aut |
| 700 | 1 | a Lax, Stephanie J.u Univ York, Dept Hlth Sci, York, N Yorkshire, England4 aut |
| 700 | 1 | a Travis, Ruth C.u Univ Oxford, Canc Epidemiol Unit, Oxford, England4 aut |
| 700 | 1 | a Kaaks, Rudolphu German Canc Res Ctr, Div Clin Epidemiol, Heidelberg, Baden Wurttembe, Germany4 aut |
| 700 | 1 | a Riboli, Eliou Imperial Coll London, Sch Publ Hlth, London, England4 aut |
| 700 | 1 | a Benavente, Yolandau CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;IDIBELL, Inst Catala Oncol, Canc Epidemiol Res Programme, Unit Infect & Canc, Barcelona 08908, Spain4 aut |
| 700 | 1 | a Brennan, Paulu Int Agcy Res Canc, Lyon, France4 aut |
| 700 | 1 | a McKay, Jamesu CHU Henri Mondor, Dept Immunol, Creteil, France4 aut |
| 700 | 1 | a Delfau-Larue, Marie-Heleneu CHU Henri Mondor, INSERM, U955, Creteil, France;CHU Henri Mondor, Dept Immunol, Creteil, France4 aut |
| 700 | 1 | a Link, Brian K.u Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA4 aut |
| 700 | 1 | a Magnani, Corradou Univ Piemonte Orientale, Unit Med Stat & Epidemiol, Dept Translat Med, Novara, Italy;Univ Piemonte Orientale, Ctr Oncol Prevent CPO Piemonte, Novara, Italy4 aut |
| 700 | 1 | a Ennas, Maria Graziau Univ Cagliari, Dept Biomed Sci, Cagliari, Italy4 aut |
| 700 | 1 | a Latte, Giancarlou S Francesco Hosp, Div Hematol, Nuoro, Italy4 aut |
| 700 | 1 | a Feldman, Andrew L.u Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA4 aut |
| 700 | 1 | a Doo, Nicole Wongu Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia4 aut |
| 700 | 1 | a Giles, Graham G.u Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia4 aut |
| 700 | 1 | a Southey, Melissa C.u Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Melbourne, Vic, Australia4 aut |
| 700 | 1 | a Milne, Roger L.u Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia4 aut |
| 700 | 1 | a Offit, Kennethu Rigshosp, Dept Hematol, Copenhagen, Denmark4 aut |
| 700 | 1 | a Musinsky, Jacobu Rigshosp, Dept Hematol, Copenhagen, Denmark4 aut |
| 700 | 1 | a Arslan, Alan A.u NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA;NYU, Dept Environm Med, Sch Med, 550 1St Ave, New York, NY 10016 USA;NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY USA4 aut |
| 700 | 1 | a Purdue, Mark P.u NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA4 aut |
| 700 | 1 | a Adami, Hans-Olovu Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden4 aut |
| 700 | 1 | a Melbye, Madsu Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA;Statens Serum Inst, Div Hlth Surveillance & Res, Dept Epidemiol Res, Copenhagen, Denmark4 aut |
| 700 | 1 | a Glimelius, Bengtu Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)bengglim |
| 700 | 1 | a Conde, Luciau UCL, UCL Canc Inst, Bill Lyons Informat Ctr, London, England4 aut |
| 700 | 1 | a Camp, Nicola J.u Univ Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT USA4 aut |
| 700 | 1 | a Glenn, Marthau Univ Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT USA4 aut |
| 700 | 1 | a Curtin, Karenu Univ Utah, Sch Med, Dept Internal Med, Huntsman Canc Inst, Salt Lake City, UT USA4 aut |
| 700 | 1 | a Clavel, Jacquelineu Univ Paris 05, Paris, France;Ctr Res Epidemiol & Stat Sorbonne Paris Cite CRES, Epidemiol Childhood & Adolescent Canc Grp, INSERM, Paris, France4 aut |
| 700 | 1 | a Monnereau, Alainu Univ Paris 05, Paris, France;Univ Bordeaux, Inst Bergonie, Registre Hemopathies Malignes Gironde, Inserm,Team EPICENE,UMR 1219, Bordeaux, France4 aut |
| 700 | 1 | a Cox, David G.u Ctr Leon Berard, INSERM, UMR1052, Canc Res Ctr Lyon, Lyon, France. Ctr Leon Berard, Dept Hematol, Lyon, France;Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England4 aut |
| 700 | 1 | a Ghesquieres, Herveu CNRS, UMR 5239, Lab Biol Mol Cellule, Pierre Benite, France;Univ Paris 05, Paris, France4 aut |
| 700 | 1 | a Salles, Gillesu CNRS, UMR 5239, Lab Biol Mol Cellule, Pierre Benite, France;Univ Claude Bernard Lyon, Lyon, France;Ctr Hosp Lyon Sud, Hosp Civils Lyon, Dept Hematol, Lyon, France4 aut |
| 700 | 1 | a Bofetta, Paulou Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA4 aut |
| 700 | 1 | a Foretova, Lenkau MF MU, Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic4 aut |
| 700 | 1 | a Staines, Anthonyu Dublin City Univ, Sch Nursing & Human Sci, Dublin, Ireland4 aut |
| 700 | 1 | a Davis, Scottu Univ Washington, Sch Publ Hlth & Community Med, Seattle, WA 98195 USA;Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA4 aut |
| 700 | 1 | a Severson, Richard K.u Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA4 aut |
| 700 | 1 | a Lan, Qingu NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA4 aut |
| 700 | 1 | a Brooks-Wilson, Angelau BC Canc Agcy, Genome Sci Ctr, Vancouver, BC, Canada;Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC, Canada4 aut |
| 700 | 1 | a Smith, Martyn T.u Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA4 aut |
| 700 | 1 | a Roman, Eveu Univ York, Dept Hlth Sci, York, N Yorkshire, England4 aut |
| 700 | 1 | a Kricker, Anneu Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW, Australia4 aut |
| 700 | 1 | a Zhang, Yaweiu Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA;Yale Sch Med, Dept Surg, New Haven, CT USA4 aut |
| 700 | 1 | a Kraft, Peteru Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA4 aut |
| 700 | 1 | a Chanock, Stephen J.u NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA4 aut |
| 700 | 1 | a Rothman, Nathanielu NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA4 aut |
| 700 | 1 | a Hartge, Patriciau NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA4 aut |
| 700 | 1 | a Skibola, Christine F.u Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA4 aut |
| 710 | 2 | a City Hope Natl Med Ctr, 1500 East Duarte Rd, Duarte, CA 91010 USA;Beckman Res Inst, Dept Populat Sci, Duarte, CA USAb Ragon Inst MGH MIT & Harvard, Cambridge, MA USA;Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc & Inflammat Program, Frederick, MD USA4 org |
| 773 | 0 | t Cancer Researchg 78:14, s. 4086-4096q 78:14<4086-4096x 0008-5472x 1538-7445 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362009 |
| 856 | 4 8 | u https://doi.org/10.1158/0008-5472.CAN-17-2900 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:138766976 |
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