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Interferon-gamma an...
Interferon-gamma and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0-2 Years Prenatally Exposed to Plasmodium falciparum : Tanzanian Birth Cohort
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- Sylvester, Boniphace (författare)
- Muhimbili Univ Hlth & Allied Sci, Sch Publ Hlth & Social Sci, Dept Parasitol & Med Entomol, POB 65001, Dar Es Salaam, Tanzania
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- Gasarasi, Dinah B. (författare)
- Muhimbili Univ Hlth & Allied Sci, Sch Publ Hlth & Social Sci, Dept Parasitol & Med Entomol, POB 65001, Dar Es Salaam, Tanzania
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- Aboud, Said (författare)
- Muhimbili Univ Hlth & Allied Sci, Sch Med, Dept Microbiol & Immunol, POB 65001, Dar Es Salaam, Tanzania
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- Tarimo, Donath (författare)
- Muhimbili Univ Hlth & Allied Sci, Sch Publ Hlth & Social Sci, Dept Parasitol & Med Entomol, POB 65001, Dar Es Salaam, Tanzania
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- Masawe, Siriel (författare)
- Muhimbili Univ Hlth & Allied Sci, Sch Med, Dept Obstet & Gynaecol, POB 65001, Dar Es Salaam, Tanzania
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- Mpembeni, Rose (författare)
- Muhimbili Univ Hlth & Allied Sci, Sch Publ Hlth & Social Sci, Dept Epidemiol & Biostat, Dar Es Salaam, Tanzania
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- Swedberg, Göte (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
- HINDAWI LTD, 2018
- 2018
- Engelska.
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Ingår i: Journal of Tropical Medicine. - : HINDAWI LTD. - 1687-9686 .- 1687-9694.
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Abstract
Ämnesord
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- Background: Infants born to mothers with placental malaria are prenatally exposed to Plasmodium falciparum antigens. However, the effect of that exposure to subsequent immune responses has not been fully elucidated. This study aimed at determining the effect of prenatal exposure to P. falciparum on Interleukin-10 and Interferon-gamma responses during clinical malaria episodes in the first 24 months of life.Methods: This prospective cohort study involved 215 infants aged 0-2 years born to mothers with or without placental malaria. Enzyme-linked immunosorbent assay (ELISA) was used to determine levels of IL-10 and IFN-gamma in infants and detect IgM in cord blood. Data were analyzed using SPSS version 20.Findings: Geometric mean for IFN-gamma in exposed infants was 557.9 pg/ml (95% CI: 511.6-604.1) and in unexposed infants it was 634.4 pg/ml (95% CI: 618.2-668.5) (P=0.02). Mean IL-10 was 22.4 pg/ml (95% CI: 19.4-28.4) and 15.1 pg/ml (95% CI: 12.4-17.6), respectively (P=0.01).Conclusions: Prenatal exposure to P. falciparum antigens significantly affects IL-10 and IFN-gamma responses during clinical malaria episodes in the first two years of life.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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