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Pregnancy complicat...
Pregnancy complications and subsequent breast cancer risk in the mother : a Nordic population-based case-control study
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- Troisi, Rebecca (författare)
- NCI, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Ording, Anne Gulbech (författare)
- Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark
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- Grotmol, Tom (författare)
- Canc Registry Norway, Oslo, Norway
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- Glimelius, Ingrid, 1975- (författare)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi,Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden
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- Engeland, Anders (författare)
- Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Oslo, Norway;Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway
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- Gissler, Mika (författare)
- Karolinska Institutet
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- Trabert, Britton (författare)
- NCI, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
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- Ekbom, Anders (författare)
- Karolinska Institutet
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- Madanat-Harjuoja, Laura (författare)
- Finnish Canc Registry, Canc Soc Finland, Helsinki, Finland;Univ Helsinki, Dept Pediat, Helsinki, Finland;Helsinki Univ Hosp, Helsinki, Finland
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- Sorensen, Henrik Toft (författare)
- Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark
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- Tretli, Steinar (författare)
- Canc Registry Norway, Oslo, Norway
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- Bjorge, Tone (författare)
- Canc Registry Norway, Oslo, Norway;Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway
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(creator_code:org_t)
- 2018-08-10
- 2018
- Engelska.
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Ingår i: International Journal of Cancer. - : WILEY. - 0020-7136 .- 1097-0215. ; 143:8, s. 1904-1913
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Certain features of pregnancy are important risk factors for breast cancer, such as protection afforded by young age at first birth. Preeclampsia, a pregnancy complication, is associated with reduced maternal breast cancer risk. However, questions remain regarding causality, biological mechanisms and the relation of other hypertensive conditions to risk. We conducted a population-based case-control study of breast cancer cases (n = 116,196) in parous women identified through linkage of birth and cancer registries in Denmark, Finland, Norway and Sweden (1967-2013), including up to 10 matched controls per case (n = 1,147,192) sampled from the birth registries (complete data were not available on all variables). Odds ratios (ORs) with 95% confidence intervals (CIs) were derived from unconditional logistic regression models including matching factors (country, maternal birth year) and parity. Hypertension diagnosed before pregnancy (OR 0.87; 95% CI 0.78-0.97), gestational hypertension (OR 0.90; 95% CI 0.86-0.93) and preeclampsia (OR 0.91; 95% CI 0.88-0.95) were associated with reduced breast cancer risk. Results remained similar after adjustment for smoking and maternal body mass index before first pregnancy, and were generally similar stratified by parity, age at breast cancer diagnosis, time since first and last birth, sex of the offspring and calendar time. Except for retained placenta (OR 1.14; 95% CI 0.98-1.32), no other pregnancy complication appeared associated with breast cancer risk. The mechanisms mediating the modest risk reductions for history of preeclampsia or hypertension preceding or arising during pregnancy, and possible increased risk with history of retained placenta are unknown and warrant further laboratory, clinical and epidemiological investigation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- breast cancer
- Nordic countries
- pregnancy
- preeclampsia
- hypertension
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Troisi, Rebecca
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Ording, Anne Gul ...
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Grotmol, Tom
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Glimelius, Ingri ...
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Engeland, Anders
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Gissler, Mika
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visa fler...
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Trabert, Britton
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Ekbom, Anders
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Madanat-Harjuoja ...
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Sorensen, Henrik ...
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Tretli, Steinar
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Bjorge, Tone
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Uppsala universitet
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Karolinska Institutet